Irsogladine maleate

Cat. No. 2504

Irsogladine maleate C9H7Cl2N5.C4H4O4 [84504-69-8]

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Alternative Name: MN 1695

Chemical Name: 6-(2,5-Dichlorophenyl)-1,3,5-triazine-2,4-diamine maleate

Biological Activity

Phosphodiesterase 4 (PDE4) inhibitor that displays gastroprotective properties. Prevents gastric mucosal injury induced by monochloramine and ischemia-reperfusion. Activates gap-junctional intercellular communication improving gastric mucosal barrier function. Inhibits superoxide production in human neutrophils and inhibits in vitro and in vivo angiogenesis.

Technical Data

M.Wt:
372.18
Formula:
C9H7Cl2N5.C4H4O4
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:
>99 %
Storage:
Desiccate at RT
CAS No:
84504-69-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Kyoi et al (2004) Phosphodiesterase type IV inhibitors prevent ischemia-reperfusion-induced gastric injury in rats. J.Pharmacol.Sci. 95 321. PMID: 15272207.

Kyoi et al (2004) Irsogladine, an anti-ulcer drug, suppresses superoxide production by inhibiting phosphodiesterase type 4 in human neutrophils. Life Sci. 76 71. PMID: 15501481.

Nozaki et al (2004) Inhibition of breast cancer regrowth and pulmonary metastasis in nude mice by anti-gastric ulcer agent, irsogladine. Breast Cancer Res.Treat. 83 195. PMID: 14758089.

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Keywords: Irsogladine maleate, supplier, PDE4, inhibitors, inhibits, antiulcer, agent, Phosphodiesterases, MN1695, Tocris Bioscience, Phosphodiesterase Inhibitor products

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