(-)-Bicuculline methiodide

Cat. No. 2503

(-)-Bicuculline methiodide C21H20INO6 [40709-69-1]

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Chemical Name: [R-(R*,S*)]-5-(6,8-Dihydro-8-oxofuro[3,4-e]-1,3-benzodioxol-6-yl)-5,6,7,8-tetrahydro-6,6-dimethyl-1,3-dioxolo[4,5-g]isoquinolinium iodide

Biological Activity

Methiodide form of classical GABAA receptor antagonist (+)-bicuculline (Cat. No. 0130). More water-soluble and stable. Non-GABA receptor-mediated actions reported, including actions on calcium-dependent potassium channels.

Technical Data

M.Wt:
509.3
Formula:
C21H20INO6
Solubility:
Soluble to 20 mM in water and to 50 mM in DMSO
Purity:
>99 %
Storage:
Store at RT
CAS No:
40709-69-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

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Chan et al (2006) Blockade of GABA(A) receptors in the ventromedial hypothalamus further stimulates glucagon and sympathoadrenal but not the hypothalamo-pituitary-adrenal response to hypoglycemia. Diabetes 55 1080. PMID: 16567532.

Kurt et al (2006) Differential effects of iontophoretic in vivo application of the GABAA-antagonists bicuculline and gabazine in sensory cortex. Hear.Res. 212 224. PMID: 16442250.

Seutin and Johnson (1999) Recent advances in the pharmacology of quaternary salts of bicuculline. TiPS 20 268. PMID: 10390643.

Olsen et al (1976) Studies on the neuropharmacological activity of bicuculline and related compounds. Brain Res. 102 283. PMID: 1247886.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for (-)-Bicuculline methiodide include:

Cichon and Gan (2015) Branch-specific dendritic Ca(2+) spikes cause persistent synaptic plasticity. Nature 520 180. PMID: 25822789.

Fehérvári et al (2015) In Vivo Voltage-Sensitive Dye Study of Lateral Spreading of Cortical Activity in Mouse Primary Visual Cortex Induced by a Current Impulse. PLoS One 10 e0133853. PMID: 26230520.

Kempf et al (2014) The sphingolipid receptor S1PR2 is a receptor for Nogo-a repressing synaptic plasticity. PLoS Biol 12 e1001763. PMID: 24453941.

Pedroni et al (2014) Electrophysiological characterization of granule cells in the dentate gyrus immediately after birth. Front Cell Neurosci 8 44. PMID: 24592213.

Benton et al (2013) Iberiotoxin-sensitive and -insensitive BK currents in Purkinje neuron somata. J Neurophysiol 109 2528. PMID: 23446695.

Janczewski et al (2013) Role of inhibition in respiratory pattern generation. J Neurosci 33 5454. PMID: 23536061.

He et al (2012) Increased Kv1 channel expression may contribute to decreased sIPSC frequency following chronic inhibition of NR2B-containing NMDAR. Neuropsychopharmacology 37 1338. PMID: 22218089.

Platt et al (2012) Striatal dopamine transmission is subtly modified in human A53Tα-synuclein overexpressing mice. PLoS One 7 e36397. PMID: 22570709.

Gallo and Iadecola (2011) Neuronal nitric oxide contributes to neuroplasticity-associated protein expression through cGMP, protein kinase G, and extracellular signal-regulated kinase. J Neurosci 31 6947. PMID: 21562256.

Zemkova et al (2011) Norepinephrine causes a biphasic change in mammalian pinealocye membrane potential: role of alpha1B-adrenoreceptors, phospholipase C, and Ca2+. Endocrinology 152 3842. PMID: 21828176.

Jackson et al (2010) Control of cerebellar long-term potentiation by P-Rex-family guanine-nucleotide exchange factors and phosphoinositide 3-kinase. PLoS One 5 e11962. PMID: 20694145.

Terasaki et al (2010) Activation of NR2A receptors induces ischemic tolerance through CREB signaling. J Cereb Blood Flow Metab 30 1441. PMID: 20145658.

Bortone and Polleux (2009) KCC2 expression promotes the termination of cortical interneuron migration in a voltage-sensitive calcium-dependent manner. Neuron 62 53. PMID: 19376067.

Young et al (2007) Glutamate receptor expression and chronic glutamate toxicity in rat motor cortex. Neurobiol Dis 26 78. PMID: 17240155.

Do you know of a great paper that uses (-)-Bicuculline methiodide from Tocris? If so please let us know.show all ▼show less ▲

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Keywords: (-)-Bicuculline methiodide, supplier, Water-soluble, GABAA, antagonists, Receptors, Tocris Bioscience, GABAA Receptor Antagonist products

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