[Leu31,Pro34]-Neuropeptide Y (human, rat)

Cat. No. 1176

[Leu31,Pro34]-Neuropeptide Y (human, rat) Tyr-Pro-Ser-Lys-Pro-Asp-Asn-Pro-Gly-Glu-Asp-Ala-Pro-Ala-Glu-Asp-Met-Ala-Arg-Tyr-Tyr-Ser-Ala-Leu-Arg-His-Tyr-Ile-Asn-Leu-Leu-Thr-Arg-Pro-Arg-Tyr-NH2

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Alternative Name: [Leu31,Pro34]-NPY (human)

Biological Activity

High affinity neuropeptide Y Y1 receptor agonist (Ki = 0.39 nM). Also shows affinity for Y4 and Y5 receptors.

Technical Data

M.Wt:
4241
Formula:
C189H284N54O56S
Sequence:
YPSKPDNPGEDAPAEDMARYYSALRHYINLLTRPRY

(Modifications: Tyr-36 = C-terminal amide)

Solubility:
Soluble to 1 mg/ml in water
Storage:
Store at -20°C
CAS No:
132699-73-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

Certificate of Analysis / Product Datasheet
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References are publications that support the products' biological activity.

Kask et al (1998) Evidence for involvement of neuropeptide Y receptors in the regulation of food intake: studies with Y1-selective antagonist BIBP3226. Br.J.Pharmacol. 124 1507. PMID: 9723965.

Michel et al (1998) XVI.International Union of Pharmacology recommendations for the nomenclature of neuropeptide Y, peptide YY, and pancreatic polypeptide receptors. Pharmacol.Rev. 50 143. PMID: 9549761.

Bard et al (1995) Cloning and functional expression of a human Y4 subtype receptor for pancreatic polypeptide, neuropeptide Y, and peptide YY. J.Biol.Chem. 270 26762. PMID: 7592911.

Fuhlendorff et al (1990) [Leu31, Pro34]Neuropeptide Y: a specific Y1 receptor agonist. Proc.Natl.Acad.Sci.U.S.A. 87 182. PMID: 2153286.

If you know of a relevant reference for [Leu31,Pro34]-Neuropeptide Y (human, rat) please let us know.

Citations are publications that use Tocris products. Selected citations for [Leu31,Pro34]-Neuropeptide Y (human, rat) include:

Malet (2017) Spinal activation of the NPY Y1 receptor reduces mechanical and cold allodynia in rats with chronic constriction injury. Peptides 92 38. PMID: 28465077.

Do you know of a great paper that uses [Leu31,Pro34]-Neuropeptide Y (human, rat) from Tocris? If so please let us know.

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Keywords: [Leu31,Pro34]-Neuropeptide Y (human, rat), supplier, NPY, Y1, receptor, agonists, Neuropeptide, Y, Receptors, [Leu31Pro34]-NeuropeptideY, (human,, rat), neuropeptides, Tocris Bioscience, NPY Receptor Agonist products

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