KT 5720

Cat. No. 1288

KT 5720 C32H31N3O5 [108068-98-0]

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Chemical Name: (9R,10S,12S)-2,3,9,10,11,12-Hexahydro-10-hydroxy-9-methyl-1-oxo-9,12-epoxy-1H-diindolo[1,2,3-fg:3',2',1'-kl]pyrrolo[3,4-i][1,6]benzodiazocine-10-carboxylic acid, hexyl ester

Biological Activity

Potent, selective inhibitor of protein kinase A (Ki = 60 nM). Has no effect on PKG or PKC (Ki > 2 μM). Reversibly arrests human skin fibroblasts in the G1 phase.

Technical Data

M.Wt:
537.61
Formula:
C32H31N3O5
Solubility:
Soluble to 50 mM in DMSO
Purity:
>98 %
Storage:
Desiccate at -20°C
CAS No:
108068-98-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

Certificate of Analysis / Product Datasheet
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References are publications that support the products' biological activity.

Cabell et al (1993) Effects of selective inhibition of protein kinase C, cyclic AMP-dependent protein kinase, and Ca(2+)-calmodulin-dependent protein kinase on neurite development in cultured rat hippocampal neurons. Int.J.Dev. Neurosci. 11 357. PMID: 7689287.

Gadbois et al (1992) Multiple kinase arrest points in the G1 phase of nontransformed mammalian cells are absent in transformed cells. Proc.Natl.Acad.Sci.U.S.A. 89 8626. PMID: 1528872.

Kase et al (1987) K-252 compounds, novel and potent inhibitors of protein kinase C and cyclic nucleotide-dependent protein kinases. Biochem.Biophys.Res.Commun. 142 436. PMID: 3028414.

If you know of a relevant reference for KT 5720 please let us know.

Citations are publications that use Tocris products. Selected citations for KT 5720 include:

Cornelison et al (2016) Elevated levels of calcitonin gene-related peptide in upper spinal cord promotes sensitization of primary trigeminal nociceptive neurons Neuroscience 339 491. PMID: 27746346.

Brignell et al (2015) Steady-state modulation of voltage-gated K+ channels in rat arterial smooth muscle by cyclic AMP-dependent protein kinase and protein phosphatase 2B. J Neurosci 10 e0121285. PMID: 25793374.

Merino et al (2015) Glucagon Increases Beating Rate but Not Contractility in Rat Right Atrium. Comparison with Isoproterenol. Br J Pharmacol 10 e0132884. PMID: 26222156.

Parnell et al (2015) Phosphorylation of ezrin on Thr567 is required for the synergistic activation of cell spreading by EPAC1 and protein kinase A in HEK293T cells. Invest Ophthalmol Vis Sci 1853 1749. PMID: 25913012.

Smith et al (2015) The Effects of the Endocannabinoids Anandamide and 2-Arachidonoylglycerol on Human Osteoblast Proliferation and Differentiation. PLoS One 10 e0136546. PMID: 26414859.

Thakran et al (2015) Pioglitazone restores IGFBP-3 levels through DNA PK in retinal endothelial cells cultured in hyperglycemic conditions. PLoS One 56 177. PMID: 25525174.

Guo and Feng (2012) OX2R activation induces PKC-mediated ERK and CREB phosphorylation. Exp Cell Res 318 2004. PMID: 22652455.

Hook et al (2012) Dopaminergic modulation of ganglion-cell photoreceptors in rat. Biochim Biophys Acta 35 507. PMID: 22304466.

Lee et al (2012) The calcium-sensing receptor regulates the NLRP3 inflammasome through Ca2+ and cAMP. Nature 492 123. PMID: 23143333.

Nakao et al (2012) The role of mislocalized phototransduction in photoreceptor cell death of retinitis pigmentosa. PLoS One 7 e32472. PMID: 22485131.

Meitzen et al (2011) β1-Adrenergic receptors activate two distinct signaling pathways in striatal neurons. J Neurochem 116 984. PMID: 21143600.

Sowa et al (2010) Prostatic acid phosphatase reduces thermal sensitivity and chronic pain sensitization by depleting phosphatidylinositol 4,5-bisphosphate. J Neurosci 30 10282. PMID: 20685973.

O'Riordan et al (2006) Regulation of nuclear factor κB in the hippocampus by group I metabotropic glutamate receptors. PLoS One 26 4870. PMID: 16672661.

Do you know of a great paper that uses KT 5720 from Tocris? If so please let us know.show all ▼show less ▲

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Keywords: KT 5720, supplier, Selective, protein, kinases, A, inhibitors, inhibits, PKA, cAMP, KT5720, Tocris Bioscience, Protein Kinase A Inhibitor products

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