DR 2313

Cat. No. 2496

DR 2313 C8H10N2OS [284028-90-6]

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Chemical Name: 1,5,7,8-Tetrahydro-2-methyl-4H-thiopyrano[4,3-d]pyrimidin-4-one

Biological Activity

Competitive inhibitor of poly(ADP-ribose) polymerase (PARP) (IC50 values are 0.20 and 0.24 μM for PARP-1 and PARP-2 respectively). Neuroprotective; reduces neuronal cell death in models of cerebral ischemia in vivo and in vitro. Brain penetrant.

Technical Data

M.Wt:
182.24
Formula:
C8H10N2OS
Solubility:
Soluble to 40 mM in water
Purity:
>99 %
Storage:
Store at +4°C
CAS No:
284028-90-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Jagtap and Szabo (2005) Poly(ADP-ribose) polymerase and the therapeutic effects of its inhibitors. Nat.Rev.Drug Discov. 4 421. PMID: 15864271.

Nakajima et al (2005) A newly synthesized poly(ADP-ribose) polymerase inhibitor, DR2313 [2-Methyl-3,5,7,8-tetrahydrothiopyrano[4,3-d]-pyrimidine-4-one]: pharmacological profiles, neuroprotective effects, and therapeutic time window in cerebral ischemia in rats. J.Pharmacol.Exp.Ther. 312 472. PMID: 15466246.

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Keywords: DR 2313, supplier, Potent, PARP, inhibitors, inhibits, PolyADP-ribose, Polymerase, Polymerases, DR2313, Tocris Bioscience, Poly(ADP-Ribose) Polymerase Inhibitor products

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