Cat. No. 2496
Chemical Name: 1,5,7,8-Tetrahydro-2-methyl-4H-thio
Biological ActivityCompetitive inhibitor of poly(ADP-ribose) polymerase (PARP) (IC50 values are 0.20 and 0.24 μM for PARP-1 and PARP-2 respectively). Neuroprotective; reduces neuronal cell death in models of cerebral ischemia in vivo and in vitro. Brain penetrant.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Jagtap and Szabo (2005) Poly(ADP-ribose) polymerase and the therapeutic effects of its inhibitors. Nat.Rev.Drug Discov. 4 421. PMID: 15864271.
Nakajima et al (2005) A newly synthesized poly(ADP-ribose) polymerase inhibitor, DR2313 [2-Methyl-3,5,7,8-tetrahydrothiopyrano[4,3-d]-pyrimidine-4-one]: pharmacological profiles, neuroprotective effects, and therapeutic time window in cerebral ischemia in rats. J.Pharmacol.Exp.Ther. 312 472. PMID: 15466246.
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Keywords: DR 2313, supplier, Potent, PARP, inhibitors, inhibits, PolyADP-ribose, Polymerase, Polymerases, DR2313, Tocris Bioscience, Poly(ADP-Ribose) Polymerase Inhibitor products
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