Melperone hydrochloride

Cat. No. 2495

Melperone hydrochloride C16H22FNO.HCl [1622-79-3]

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Chemical Name: 1-(4-Fluorophenyl)-4-(4-methyl-1-piperidinyl)-1-butanone hydrochloride

Biological Activity

Atypical neuroleptic; 5-HT2A/D2 receptor antagonist (Ki values are 120 and 180 nM respectively). Causes an increase in dopamine levels in the medial prefrontal cortex (mPFC) and nucleus accumbens and an increase in ACh in the mPFC. Also binds adrenergic α1 and α2 receptors (Ki values are 180 and 150 nM respectively).

Technical Data

Soluble to 100 mM in water and to 100 mM in DMSO
>99 %
Desiccate at RT

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Uhr et al (2005) P-glycoprotein is a factor in the uptake of dextromethorphan, but not of melperone, into mouse brain: evidence for an overlap in substrate specificity between P-gp and CYP2D6. J.Psychopharmacol. 18 509.

Ichikawa et al (2002) Atypical antipsychotic drugs, quetiapine, iloperidone, and melperone, preferentially increase dopamine and acetylcholine release in rat medial prefrontal cortex: role of 5-HT1A receptor agonism. Brain Res. 956 349. PMID: 12445705.

Seeman et al (1997) Atypical neuroleptics have low affinity for dopamine D2 receptors or are selective for D4 receptors. Neuropsychopharmacology. 16 93. PMID: 9015795.

If you know of a relevant reference for Melperone hydrochloride please let us know.

Citations are publications that use Tocris products. Selected citations for Melperone hydrochloride include:

Hacker et al (2015) Substrate-Dependent Inhibition of the Human Organic Cation Transporter OCT2: A Comparison of Metformin with Experimental Substrates. Brain Res 10 e0136451. PMID: 26327616.

Do you know of a great paper that uses Melperone hydrochloride from Tocris? If so please let us know.

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Keywords: Melperone hydrochloride, supplier, 5-HT2A/D2, receptor, antagonists, neuroleptic, Serotonin, Receptors, Dopamine, D2, dopaminergic, Tocris Bioscience, 5-HT2A Receptor Antagonist products

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