Cat. No. 0582
Alternative Name: Metitepine
Chemical Name: 1-[10,11-Dihydro-8-(methylthio)dibe
Biological ActivityPotent 5-HT2 antagonist, also active as 5-HT1 antagonist. Differentiates 5-HT1D sub-types. Also displays affinity for rodent 5-HT5B, 5-HT5A, 5-HT7 and 5-HT6 receptors (pK1 values are 6.6, 7.0, 8.4 and 8.7 respectively).
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Wilkinson and Middlemiss (1992) Metitepine distinguishes two receptors mediating inhibition of [3H]-5-hydroxytryptamine release in guinea pig hippocampus. Naunyn Schmiedebergs Arch.Pharmacol. 345 696. PMID: 1321958.
Hoyer (1989) The peripheral actions of 5-HT. Ed. Fozard. Oxford..
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Keywords: Methiothepin maleate, supplier, moderate, affinity, 5-ht5, high, 5-ht6, 5-HT7, antagonists, 5-HT1, 5-HT2, Serotonin, 5-HT-, 5-Hydroxytryptamine, Receptors, 5-HT, Tocris Bioscience, Non-selective 5-HT products
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