Methiothepin maleate

Cat. No. 0582

Methiothepin maleate C20H24N2S2.C4H4O4 [19728-88-2]

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Alternative Name: Metitepine

Chemical Name: 1-[10,11-Dihydro-8-(methylthio)dibenzo(Z)[b,f]thiepin-10-yl]-4-methylpiperazine maleate

Biological Activity

Potent 5-HT2 antagonist, also active as 5-HT1 antagonist. Differentiates 5-HT1D sub-types. Also displays affinity for rodent 5-HT5B, 5-HT5A, 5-HT7 and 5-HT6 receptors (pK1 values are 6.6, 7.0, 8.4 and 8.7 respectively).

Technical Data

M.Wt:
472.62
Formula:
C20H24N2S2.C4H4O4
Solubility:
Soluble to 100 mM in DMSO
Purity:
>99 %
Storage:
Store at RT
CAS No:
19728-88-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

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Wilkinson and Middlemiss (1992) Metitepine distinguishes two receptors mediating inhibition of [3H]-5-hydroxytryptamine release in guinea pig hippocampus. Naunyn Schmiedebergs Arch.Pharmacol. 345 696. PMID: 1321958.

Hoyer (1989) The peripheral actions of 5-HT. Ed. Fozard. Oxford..

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Keywords: Methiothepin maleate, supplier, moderate, affinity, 5-ht5, high, 5-ht6, 5-HT7, antagonists, 5-HT1, 5-HT2, Serotonin, 5-HT-, 5-Hydroxytryptamine, Receptors, 5-HT, Tocris Bioscience, Non-selective 5-HT products

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