Methiothepin maleate

Cat. No. 0582

Methiothepin maleate C20H24N2S2.C4H4O4 [19728-88-2]

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Alternative Name: Metitepine

Chemical Name: 1-[10,11-Dihydro-8-(methylthio)dibenzo(Z)[b,f]thiepin-10-yl]-4-methylpiperazine maleate

Biological Activity

Potent 5-HT2 antagonist, also active as 5-HT1 antagonist. Differentiates 5-HT1D sub-types. Also displays affinity for rodent 5-HT5B, 5-HT5A, 5-HT7 and 5-HT6 receptors (pK1 values are 6.6, 7.0, 8.4 and 8.7 respectively).

Technical Data

Soluble to 100 mM in DMSO
>99 %
Store at RT

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Wilkinson and Middlemiss (1992) Metitepine distinguishes two receptors mediating inhibition of [3H]-5-hydroxytryptamine release in guinea pig hippocampus. Naunyn Schmiedebergs Arch.Pharmacol. 345 696. PMID: 1321958.

Hoyer (1989) The peripheral actions of 5-HT. Ed. Fozard. Oxford..

If you know of a relevant reference for Methiothepin maleate please let us know.

Citations are publications that use Tocris products. Selected citations for Methiothepin maleate include:

Conley et al (2015) Evaluation of AaDOP2 receptor antagonists reveals antidepressants and antipsychotics as novel lead molecules for control of the yellow fever mosquito, Aedes aegypti. Oncotarget 352 53. PMID: 25332454.

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Keywords: Methiothepin maleate, supplier, moderate, affinity, 5-ht5, high, 5-ht6, 5-HT7, antagonists, 5-HT1, 5-HT2, Serotonin, 5-HT-, 5-Hydroxytryptamine, Receptors, 5-HT, Tocris Bioscience, Non-selective 5-HT products

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