cis-ACBD

Cat. No. 0271

cis-ACBD C6H9NO4 [73550-55-7]

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Chemical Name: cis-1-Aminocyclobutane-1,3-dicarboxylic acid

Biological Activity

Potent, competitive and selective inhibitor of glutamate uptake. Certain confusion exists over the naming of this compound because of apparent contradictions in the literature. This is the isomer which has the carboxylic acid and the amino groups on the same side of the cyclobutyl ring.

Technical Data

M.Wt:
159.14
Formula:
C6H9NO4
Solubility:
Soluble to 100 mM in 1eq. NaOH
Storage:
Store at RT
CAS No:
73550-55-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Koch et al (1999) Differentiation of substrate and nonsubstrate inhibitors of the high-affinity, sodium-dependent glutamate transporters. Mol.Pharmacol. 56 1095. PMID: 10570036.

Fletcher et al (1991) Inhibition of L-glutamic acid uptake into rat cortical synaptosomes by the conformationally restricted analogue of glutamic acid, cis-1-aminocyclobutane-1,3-dicarboxylic acid. Neurosci.Lett. 121 133. PMID: 1673544.

Allan et al (1990) Synthesis and activity of a potent NMDA agonist, trans-1-aminocyclobutane-1,3-dicarboxylic acid, and related phosphonic and carboxylic acids. J.Med.Chem. 33 2905. PMID: 2145435.

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Citations are publications that use Tocris products. Selected citations for cis-ACBD include:

Lee et al (2010) Characterisation of the expression of NMDA receptors in human astrocytes. PLoS One 5 e14123. PMID: 21152063.

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Keywords: cis-ACBD, supplier, Potent, selective, competitive, L-glutamate, uptake, inhibitors, inhibits, EAAT, Excitatory, Amino, Acid, Transporters, GLAST, GLT-1, Glutamate, Monoamine, Neurotransmitter, Tocris Bioscience, Glutamate Transporter Inhibitor products

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