VUF 5681 dihydrobromide

Cat. No. 2493

VUF 5681 dihydrobromide C11H19N3.2HBr [639089-06-8]

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Chemical Name: 4-[3-(1H-Imidazol-4-yl)propyl]piperidine dihydrobromide

Biological Activity

Potent histamine H3 receptor silent antagonist (pKi = 8.35).

Technical Data

M.Wt:
355.11
Formula:
C11H19N3.2HBr
Solubility:
Soluble to 100 mM in water and to 100 mM in DMSO
Purity:
>98 %
Storage:
Desiccate at RT
CAS No:
639089-06-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

Moreno-Delgado et al (2006) Constitutive activity of H3 autoreceptors modulates histamine synthesis in rat brain through the cAMP/PKA pathway. Neuropharmacology 51 517. PMID: 16769092.

Leurs et al (2005) The histamine H3 receptor: from gene cloning to H3 receptor drugs. Nat.Rev.Drug Discov. 4 107. PMID: 15665857.

Kitbunnadaj et al (2004) Identification of 4-(1H-imidazol-4(5)-ylmethyl)pyridine (immethridine) as a novel, potent, and highly selective histamine H3 receptor agonist. J.Med.Chem. 47 2414. PMID: 15115383.

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Keywords: VUF 5681 dihydrobromide, supplier, Potent, H3, receptor, silent, antagonists, Receptors, Histamine, histaminergic, VUF5681, dihydrobromide, Tocris Bioscience, Histamine H3 Receptor Antagonist products

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