MNITMT

Cat. No. 2492

MNITMT C7H8N6O2S [177653-76-8]

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Alternative Name: NSC 631156

Chemical Name: 4-Methyl-3-[(1-methyl-4-nitro-1H-imidazol-5-yl)thio]-4H-1,2,4-triazole

Biological Activity

Novel, non-toxic immunosuppressive agent. Inhibits human mixed lymphocyte reaction in vitro (ED50 = 2.7 μM) and prolongs skin graft survival in mice. Produces a 98.1% reduction in antibody response following oral administration in rabbits.

Technical Data

M.Wt:
240.24
Formula:
C7H8N6O2S
Solubility:
Soluble to 10 mM in water
Purity:
>99 %
Storage:
Store at +4°C
CAS No:
177653-76-8

Resources

Other Information

  • Previously sold as Cat. No. 0564

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Al-Safi et al (2003) Comparison of the effects of azathioprine and its novel non-mercaptopurine analog on antibody response in rabbits. Pol.J.Pharmacol. 55 239. PMID: 12926553.

Crawford et al (1996) Rational design of novel immunosuppressive drugs: analogues of azathioprine lacking the 6-mercaptopurine substituent retain or have enhanced immunosuppressive effects. J.Med.Chem. 39 2690. PMID: 8709098.

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Keywords: MNITMT, supplier, Immunosuppressant, NSC631156, Tocris Bioscience, Immunosuppressant products

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