Cat. No. 2492
Alternative Name: NSC 631156
Chemical Name: 4-Methyl-3-[(1-methyl-4-nitro-1H-im
Biological ActivityNovel, non-toxic immunosuppressive agent. Inhibits human mixed lymphocyte reaction in vitro (ED50 = 2.7 μM) and prolongs skin graft survival in mice. Produces a 98.1% reduction in antibody response following oral administration in rabbits.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Al-Safi et al (2003) Comparison of the effects of azathioprine and its novel non-mercaptopurine analog on antibody response in rabbits. Pol.J.Pharmacol. 55 239. PMID: 12926553.
Crawford et al (1996) Rational design of novel immunosuppressive drugs: analogues of azathioprine lacking the 6-mercaptopurine substituent retain or have enhanced immunosuppressive effects. J.Med.Chem. 39 2690. PMID: 8709098.
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Keywords: MNITMT, supplier, Immunosuppressant, NSC631156, Tocris Bioscience, Immunosuppressant products
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