Cat. No. 2491
Alternative Name: SR 57746A
Chemical Name: 1,2,3,6-Tetrahydro-1-[2-(2-naphthal
Biological ActivityOrally active, full agonist at 5-HT1A receptors. Binds rat 5-HT1A with high affinity (Ki = 2.0 nM) and is > 300-fold selective over other 5-HT receptor subtypes (IC50 > 650 nM). Increases motoneuron survival and promotes effects of NGF on neurite outgrowth in vitro. Displays neurotrophic activity in several neurodegenerative models in vivo. .
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Certificate of Analysis / Product Datasheet / Safety Datasheet
Duong et al (1999) Effect of the nonpeptide neurotrophic compound SR 57746A on the phenotypic survival of purified mouse motoneurons. Br.J.Pharmacol. 128 1385. PMID: 10602316.
Bachy et al (1993) Biochemical and electrophysiological properties of SR 57746A, a new, potent 5-HT1A receptor agonist. Fund.Clin.Pharmacol. 7 487.
Fournier et al (1993) Protective effects of SR 57746A in central and peripheral models of neurodegenerative disorders in rodents and primates. Neuroscience 55 629. PMID: 8413926.
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Keywords: Xaliproden hydrochloride, supplier, Orally, active, high, affinity, 5-HT1A, agonists, Serotonin, Receptors, SR57746A, Tocris Bioscience, 5-HT1A Receptor Agonist products
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