Metergoline

Cat. No. 0590

Metergoline C25H29N3O2 [17692-51-2]

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Chemical Name: [(8β)-1,6-Dimethylergolin-8-yl)methyl]carbamic acid phenylmethyl ester

Biological Activity

Antagonist at 5-HT1/5-HT2 with activity at 5-HT1D. Has moderate affinity for 5-HT6 and high affinity for 5-HT7.

Technical Data

M.Wt:
403.52
Formula:
C25H29N3O2
Solubility:
Soluble to 100 mM in DMSO
Storage:
Store at RT
CAS No:
17692-51-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Aulakh et al (1992) Effects of various serotonin receptor subtype selective antagonists alone and on m-chlorophenylpiperazine-induced neuroendocrine changes in rats. J.Pharmacol.Exp.Ther. 263 588. PMID: 1432690.

Bagdy et al (1992) Pharmacological characterization of serotonin receptor subtypes involved in vasopressin and plasma renin activity responses to serotonin agonists. Eur.J.Pharmacol. 210 285. PMID: 1535317.

Miller et al (1992) Agonist activity of sumatriptan and metergoline at the human 5-HT1Dβ receptor in the action of sumatriptan. Eur.J.Pharmacol. 227 99. PMID: 1330643.

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Citations are publications that use Tocris products. Selected citations for Metergoline include:

Woo et al (2007) Neuregulin-1 enhances depolarization-induced GABA release. Neuron 54 599. PMID: 17521572.

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Keywords: Metergoline, supplier, moderate, affinity, 5-HT6, high, 5-HT7, 5-HT1, 5-HT2, antagonists, 5-HT1D, ligand, Serotonin, Receptors, 5-Hydroxytryptamine, 5-HT, Non-Selective, Tocris Bioscience, Non-selective 5-HT2 Antagonist products

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