Cat. No. 0590
Chemical Name: [(8β)-1,6-Dimethylergolin-8-yl)methy
Biological ActivityAntagonist at 5-HT1/5-HT2 with activity at 5-HT1D. Has moderate affinity for 5-HT6 and high affinity for 5-HT7.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Aulakh et al (1992) Effects of various serotonin receptor subtype selective antagonists alone and on m-chlorophenylpiperazine-induced neuroendocrine changes in rats. J.Pharmacol.Exp.Ther. 263 588. PMID: 1432690.
Bagdy et al (1992) Pharmacological characterization of serotonin receptor subtypes involved in vasopressin and plasma renin activity responses to serotonin agonists. Eur.J.Pharmacol. 210 285. PMID: 1535317.
Miller et al (1992) Agonist activity of sumatriptan and metergoline at the human 5-HT1Dβ receptor in the action of sumatriptan. Eur.J.Pharmacol. 227 99. PMID: 1330643.
If you know of a relevant reference for Metergoline please let us know.
Citations are publications that use Tocris products. Selected citations for Metergoline include:
Wang (2017) Dezocine exhibits antihypersensitivity activities in neuropathy through spinal μ-opioid receptoractivation and norepinephrine reuptake inhibition. Sci Rep 7 43137. PMID: 28230181.
Woo et al (2007) Neuregulin-1 enhances depolarization-induced GABA release. Neuron 54 599. PMID: 17521572.
Do you know of a great paper that uses Metergoline from Tocris? If so please let us know.
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Keywords: Metergoline, supplier, moderate, affinity, 5-HT6, high, 5-HT7, 5-HT1, 5-HT2, antagonists, 5-HT1D, ligand, Serotonin, Receptors, 5-Hydroxytryptamine, 5-HT, Non-Selective, Tocris Bioscience, Non-selective 5-HT2 Antagonist products