Cat. No. 0660
Alternative Name: Pyrilamine maleate
Chemical Name: 2-((2-(Dimethylamino)ethyl)(p-metho
Biological ActivitySelective inverse agonist for the H1 receptor. Inhibits histamine induced inositol phosphate (InsP) production (log EC50 = -7.94) and intracellular calcium mobilization. Sequesters Gq/11 protein, reducing its availability for other receptors associated with the same signaling pathway.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Carlos et al (2004) Mepyramine, a histamine H1 receptor inverse agonist, binds perferentially to a G protein-coupled form of the receptor and sequesters G protein. J.Biol.Chem. 279 34431. PMID: 15192105.
Liu et al (1994) Does the [3H] mepyramine binding site represent the histamine H1 receptor? Re-examination of the histamine H2 receptor with quinine. J.Pharmacol.Exp.Ther. 268 959. PMID: 8114011.
Hill (1990) Distribution, properties and functional characteristics of three classes of histamine receptor. Pharmacol.Rev. 42 45. PMID: 2164693.
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Citations are publications that use Tocris products. Selected citations for Mepyramine maleate include:
Brandt et al (2003) Mast cells are required for experimental oral allergen-induced diarrhea. J Clin Invest 112 1666. PMID: 14660743.
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Keywords: Mepyramine maleate, supplier, Selective, H1, inverse, agonists, Receptors, Histamine, histaminergic, Tocris Bioscience, Histamine H1 Receptor Antagonist products