Cat. No. 0773
Chemical Name: 3,5-Dimethyl-tricyclo[184.108.40.206,7]de
Biological ActivityAn antagonist at the NMDA receptor, binding to the ion channel site. Used in the treatment of Parkinsonism.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
Parsons et al (2007) Memantine: A NMDA receptor antagonist that improves memory by restoration of homeostasis in the glutamatergic system - too little activation is bad, too much is even worse. Neuropharmacology 53 699. PMID: 17904591.
Parsons et al (1999) Memantine is a clinically well tolerated N-methyl-D-aspartate (NMDA) receptor antagonist - a review of preclinical data. Neuropharmacology 38 735. PMID: 10465680.
Chen et al (1998) Neuroprotective concentrations of the N-methyl-D-aspartate open-channel blocker memantine are effective without cytoplasmic vacuolation following post-ischemic administration and do not block maze learning or long-term potentiation. Neuroscience 86 1121. PMID: 9697119.
Zajaczkowski et al (1997) Uncompetitive NMDA receptor antagonists attenuate NMDA-induced impairment of passive avoidance learning and LTP. Neuropharmacology 36 961. PMID: 9257940.
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Citations are publications that use Tocris products. Selected citations for Memantine hydrochloride include:
Birnbaum et al (2015) Calcium flux-independent NMDA receptor activity is required for Aβ oligomer-induced synaptic loss. J Neurosci 6 e1791. PMID: 26086964.
Campbell et al (2015) Functional changes in glutamate transporters and astrocyte biophysical properties in a rodent model of focal cortical dysplasia. Invest Ophthalmol Vis Sci 8 425. PMID: 25565960.
He and Bausch (2014) Synaptic plasticity in glutamatergic and GABAergic neurotransmission following chronic memantine treatment in an in vitro model of limbic epileptogenesis. J Neurosci 77 379. PMID: 24184417.
Simma et al (2014) NMDA-receptor antagonists block B-cell function but foster IL-10 production in BCR/CD40-activated B cells. Front Cell Neurosci 12 75. PMID: 25477292.
Hedegaard et al (2012) Molecular pharmacology of human NMDA receptors. Neurochem Int 61 601. PMID: 22197913.
Kaufman et al (2012) Opposing roles of synaptic and extrasynaptic NMDA receptor signaling in cocultured striatal and cortical neurons. Cell Death Dis 32 3992. PMID: 22442066.
Fan and Cooper (2009) Glutamate-induced NFκB activation in the retina. Proc Natl Acad Sci U S A 50 917. PMID: 18836176.
Puddifoot et al (2009) Pharmacological characterization of recombinant NR1/NR2A NMDA receptors with truncated and deleted carboxy termini expressed in Xenopus laevis oocytes. Br J Pharmacol 156 509. PMID: 19154422.
Costa et al (2008) Electrophysiology and pharmacology of striatal neuronal dysfunction induced by mitochondrial complex I inhibition. J Neurosci 28 8040. PMID: 18685029.
Léveillé et al (2008) Neuronal viability is controlled by a functional relation between synaptic and extrasynaptic NMDA receptors. FASEB J 22 4258. PMID: 18711223.
Manning et al (2008) NMDA receptor blockade with memantine attenuates white matter injury in a rat model of periventricular leukomalacia. Cell Commun Signal 28 6670. PMID: 18579741.
Jaekel et al (2006) Neuroprotection associated with alternative splicing of NMDA receptors in rat cortical neurons. Neuropharmacology 147 622. PMID: 16314856.
Rzeski et al (2001) Glutamate antagonists limit tumor growth. FASEB J 98 6372. PMID: 11331750.
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Keywords: Memantine hydrochloride, supplier, NMDA, antagonists, ion, channel, site, glutamate, receptors, N-Methyl-D-Aspartate, iGluR, ionotropic, Tocris Bioscience, NMDA Receptor Antagonist products