Cat. No. 0773
Chemical Name: 3,5-Dimethyl-tricyclo[220.127.116.11,7]de
Biological ActivityAn antagonist at the NMDA receptor, binding to the ion channel site. Used in the treatment of Parkinsonism.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Parsons et al (2007) Memantine: A NMDA receptor antagonist that improves memory by restoration of homeostasis in the glutamatergic system - too little activation is bad, too much is even worse. Neuropharmacology 53 699. PMID: 17904591.
Parsons et al (1999) Memantine is a clinically well tolerated N-methyl-D-aspartate (NMDA) receptor antagonist - a review of preclinical data. Neuropharmacology 38 735. PMID: 10465680.
Chen et al (1998) Neuroprotective concentrations of the N-methyl-D-aspartate open-channel blocker memantine are effective without cytoplasmic vacuolation following post-ischemic administration and do not block maze learning or long-term potentiation. Neuroscience 86 1121. PMID: 9697119.
Zajaczkowski et al (1997) Uncompetitive NMDA receptor antagonists attenuate NMDA-induced impairment of passive avoidance learning and LTP. Neuropharmacology 36 961. PMID: 9257940.
If you know of a relevant reference for this product please let us know.
Citations are publications that use Tocris products. Selected citations for Memantine hydrochloride include:
Hedegaard et al (2012) Molecular pharmacology of human NMDA receptors. Neurochem Int 61 601. PMID: 22197913.
Puddifoot et al (2009) Pharmacological characterization of recombinant NR1/NR2A NMDA receptors with truncated and deleted carboxy termini expressed in Xenopus laevis oocytes. Br J Pharmacol 156 509. PMID: 19154422.
Costa et al (2008) Electrophysiology and pharmacology of striatal neuronal dysfunction induced by mitochondrial complex I inhibition. J Neurosci 28 8040. PMID: 18685029.
Léveillé et al (2008) Neuronal viability is controlled by a functional relation between synaptic and extrasynaptic NMDA receptors. FASEB J 22 4258. PMID: 18711223.
View Related Products by Target
View Related Products by Product Action
Keywords: Memantine hydrochloride, supplier, NMDA, antagonists, ion, channel, site, glutamate, receptors, N-Methyl-D-Aspartate, iGluR, ionotropic, Tocris Bioscience, NMDA Receptor Antagonist products
Find multiple products by catalog number
New Products in this Area
Potent NMDA receptor antagonist; NR2A selectivecis-6-Hydroxynorketamine hydrochloride
Metabolite of ketamine (Cat.No. 3131); antidepressive
Follow @Tocris on Twitter
Tocris is now actively tweeting. For regular updates on news, events and special offers, follow @Tocris on Twitter.