C 75

Cat. No. 2489

C 75 C14H22O4 [191282-48-1]

Price and Availability

For C 75 pricing & availability please select your country from the drop down menu:
By clicking submit you agree to accept a cookie from Tocris Bioscience. For details, please read our privacy and cookie policy.

Alternative Name: trans-C 75

Chemical Name: (2R*,3S*)-Tetrahydro-4-methylene-2-octyl-5-oxo-3-furancarboxylic acid

Biological Activity

Synthetic inhibitor of fatty acid synthase (FASN); inhibits fatty acid synthesis in vitro and in vivo. Displays anorectic effects. Induces apoptosis in MCF-7 xenografts and exhibits anti-tumor activity.

Technical Data

Soluble to 100 mM in 1eq. NaOH and to 100 mM in DMSO
>99 %
Store at +4°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Takahashi et al (2004) The anorexigenic fatty acid synthase inhibitor, C45, is a nonspecific neuronal activator. Endocrinology 145 184. PMID: 14512433.

Thupari et al (2004) Chronic C75 treatment of diet-induced obese mice increases fat oxidation and reduces food intake to reduce adipose mass. Am.J.Physiol.Endocrinol.Metab. 287 97.

Zhou et al (2003) Fatty acid synthase inhibition triggers apoptosis during S phase in human cancer cells. Cancer Res. 63 7330. PMID: 14612531.

Kuhajda et al (2000) Synthesis and antitumor activity of an inhibitor of fatty acid synthase. Proc.Natl.Acad.Sci. 97 3450.

If you know of a relevant reference for C 75 please let us know.

Citations are publications that use Tocris products.

Do you know of a great paper that uses C 75 from Tocris? If so please let us know.

View Related Products by Product Action

Keywords: C 75, supplier, trans-C75, transC75, C75, fatty, acid, synthase, inhibitor, enzyme, FASanorectic, anorexigenic, neuronal, activator, inhibits, inhibitors, fat, obese, apoptosis, anti-tumor, FASN, Tocris Bioscience, Fatty Acid Synthase Inhibitor products

Quick Order

Find multiple products by catalog number

divider line

Cancer Research Product Guide

Cancer Research Product Guide

Our Cancer Research Guide highlights over 750 products for cancer research. Request copy or view PDF today.

divider line

New Products in this Area

GSK 343

Potent and selective SAM-competitive EZH2 inhibitor

BRD 4770

G9a inhibitor and S-adenosyl methionine mimetic; cell permeable


Selective p300 inhibitor

UNC 2399

Biotinylated UNC 1999 (Cat.No. 4904)

PF 06726304 acetate

Highly potent and SAM-competitive EZH2 inhibitor

GSK 591 dihydrochloride

Potent and selective PRMT5 inhibitor

TP 064

Potent and selective PRMT 4 inhibitor

Sign-up for new product e-alerts
divider line

Bio-Techne Events

SENC 2017

17th National Congress of the Spanish Society of Neuroscience

September 27 - 30, 2017

Alicante, Spain