Cat. No. 2489
Alternative Name: trans-C 75
Chemical Name: (2R*,3S*)-Tetrahydro-4-methylene-2-
Biological ActivitySynthetic inhibitor of fatty acid synthase (FASN); inhibits fatty acid synthesis in vitro and in vivo. Displays anorectic effects. Induces apoptosis in MCF-7 xenografts and exhibits anti-tumor activity.
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All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Takahashi et al (2004) The anorexigenic fatty acid synthase inhibitor, C45, is a nonspecific neuronal activator. Endocrinology 145 184. PMID: 14512433.
Thupari et al (2004) Chronic C75 treatment of diet-induced obese mice increases fat oxidation and reduces food intake to reduce adipose mass. Am.J.Physiol.Endocrinol.Metab. 287 97.
Zhou et al (2003) Fatty acid synthase inhibition triggers apoptosis during S phase in human cancer cells. Cancer Res. 63 7330. PMID: 14612531.
Kuhajda et al (2000) Synthesis and antitumor activity of an inhibitor of fatty acid synthase. Proc.Natl.Acad.Sci. 97 3450.
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Keywords: C 75, supplier, trans-C75, transC75, C75, fatty, acid, synthase, inhibitor, enzyme, FASanorectic, anorexigenic, neuronal, activator, inhibits, inhibitors, fat, obese, apoptosis, anti-tumor, FASN, Tocris Bioscience, Fatty Acid Synthase Inhibitor products
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