MDL 73005EF hydrochloride

Cat. No. 0411

MDL 73005EF hydrochloride C20H26N2O4.HCl [102908-60-1]

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Chemical Name: 8-[2-(1,4-Benzodioxan-2-ylmethylamino)ethyl]-8-azaspiro[4.5]decane-7,9-dione hydrochloride

Biological Activity

Potent and selective 5-HT1A receptor antagonist. Has partial agonist properties.

Technical Data

Soluble to 25 mM in water
>98 %
Store at RT

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Buisson Defferier and Van den Buuse (1992) Cardiovascular effects of the 5-HT1A receptor ligand, MDL 73005EF, in conscious hypertensive rats. Eur.J.Pharmacol. 223 133. PMID: 1362161.

Van der Hooff and Galvan (1991) Electrophysiology of the 5-HT1A ligand MDL 73005EF in the rat hippocampal slice. Eur.J.Pharmacol. 196 291. PMID: 1893914.

Gartside et al (1990) Effects of MDL 73005EF on central pre-and-postsynaptic 5HT1A receptor function in the rat in vivo. Eur.J.Pharmacol. 191 391. PMID: 1964908.

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Citations are publications that use Tocris products.

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