HC 030031

Cat. No. 2896

HC 030031 C18H21N5O3 [349085-38-7]

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Chemical Name: 2-(1,3-Dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)-N-(4-isopropylphenyl)acetamide

Biological Activity

Selective TRPA1 channel blocker that antagonizes AITC- and formalin-evoked calcium influx (IC50 values are 6.2 and 5.3 μM respectively). Does not block currents mediated by TRPV1, TRPV3, TRPV4, hERG or NaV1.2 channels. Inhibits AITC- and formalin-induced flinching in vivo.

Technical Data

Soluble to 100 mM in DMSO
>99 %
Store at RT

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

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Taylor-Clark et al (2008) Prostaglandin-induced activation of nociceptive neurons via direct interactions with TRPA1. Mol.Pharmacol. 73 274. PMID: 18000030.

McNamara et al (2007) TRPA1 mediates formalin-induced pain. Proc.Natl.Acad.Sci.USA 104 13525.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for HC 030031 include:

Fernandes et al (2016) Environmental cold exposure increases blood flow and affects pain sensitivity in the knee joints of CFA-induced arthritic mice in a TRPA1-dependent manner. Mol Pain 18 7. PMID: 26754745.

Mueller-Tribbensee et al (2015) Differential Contribution of TRPA1, TRPV4 and TRPM8 to Colonic Nociception in Mice. PLoS One 10 e0128242. PMID: 26207981.

Paulsen et al (2015) Structure of the TRPA1 ion channel suggests regulatory mechanisms. Nature 520 511. PMID: 25855297.

Ruparel et al (2015) Released lipids regulate transient receptor potential channel (TRP)-dependent oral cancer pain. Nat Commun 11 30. PMID: 26007300.

Sałat and Filipek (2015) Antinociceptive activity of transient receptor potential channel TRPV1, TRPA1, and TRPM8 antagonists in neurogenic and neuropathic pain models in mice. J Neurosci 16 167. PMID: 25743118.

Shi et al (2015) Alterations in serotonin, transient receptor potential channels and protease-activated receptors in rats with irritable bowel syndrome attenuated by Shugan decoction. Arthritis Res Ther 21 4852. PMID: 25944998.

Wang et al (2015) Hydrogen sulfide-induced itch requires activation of Cav3.2 T-type calcium channel in mice. World J Gastroenterol 5 16768. PMID: 26602811.

Aubdool et al (2014) TRPA1 is essential for the vascular response to environmental cold exposure. J Zhejiang Univ Sci B 5 5732. PMID: 25501034.

Bodkin et al (2014) Investigating the potential role of TRPA1 in locomotion and cardiovascular control during hypertension. Pharmacol Res Perspect 2 e00052. PMID: 25505598.

Hsu et al (2013) Hydrogen sulfide induces hypersensitivity of rat capsaicin-sensitive lung vagal neurons: role of TRPA1 receptors. Am J Physiol Regul Integr Comp Physiol 305 R769. PMID: 23842678.

Nesuashvili et al (2013) Sensory nerve terminal mitochondrial dysfunction activates airway sensory nerves via transient receptor potential (TRP) channels. Mol Pharmacol 83 1007. PMID: 23444014.

Gregus et al (2012) Spinal 12-lipoxygenase-derived hepoxilin A3 contributes to inflammatory hyperalgesia via activation of TRPV1 and TRPA1 receptors. Proc Natl Acad Sci U S A 109 6721. PMID: 22493235.

Kunkler et al (2011) TRPA1 receptors mediate environmental irritant-induced meningeal vasodilatation. Pain 152 38. PMID: 21075522.

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Keywords: HC 030031, supplier, Selective, TRPA1, blockers, Channels, Transient, Receptor, Potential, HC030031, Tocris Bioscience, TRPA1 Blocker products

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