Glycyl-H 1152 dihydrochloride

Cat. No. 2485

Glycyl-H-1152 dihydrochloride C18H24N4O3S.2HCl [913844-45-8]

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Chemical Name: (S)-(+)-4-Glycyl-2-methyl-1-[(4-methyl-5-isoquinolinyl)sulfonyl]-hexahydro-1H-1,4-diazepine dihydrochloride

Biological Activity

Glycyl analog of the Rho-kinase inhibitor H 1152 dihydrochloride (Cat. No. 2414) that displays improved ROCKII selectivity. IC50 values are 0.0118, 2.35, 2.57, 3.26, > 10 and >10 μM for ROCKII, Aurora A, CAMKII, PKG, PKA and PKC respectively.

Technical Data

M.Wt:
449.4
Formula:
C18H24N4O3S.2HCl
Solubility:
Soluble to 100 mM in water and to 50 mM in DMSO
Purity:
>99 %
Storage:
Desiccate at RT
CAS No:
913844-45-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Tamura et al (2005) Development of specific Rho-kinase inhibitors and their clinical application. Biochim.Biophys.Acta 1754 245. PMID: 16213195.

If you know of a relevant reference for Glycyl-H 1152 dihydrochloride please let us know.

Citations are publications that use Tocris products. Selected citations for Glycyl-H 1152 dihydrochloride include:

Araki et al (2015) Rapid dispersion of SynGAP from synaptic spines triggers AMPA receptor insertion and spine enlargement during LTP. PLoS One 85 173. PMID: 25569349.

Lawrence et al (2015) Transport of organic anions and cations in murine embryonic kidney development and in serially-reaggregated engineered kidneys. Sci Rep 5 9092. PMID: 25766625.

Sadaie et al (2015) Cell-based screen for altered nuclear phenotypes reveals senescence progression in polyploid cells after Aurora kinase B inhibition. Mol Biol Cell 26 2971. PMID: 26133385.

Siegel et al (2010) Contribution of human amniotic fluid stem cells to renal tissue formation depends on mTOR. Hum Mol Genet 19 3320. PMID: 20542987.

Do you know of a great paper that uses Glycyl-H 1152 dihydrochloride from Tocris? If so please let us know.show all ▼show less ▲

View Related Products by Product Action

Keywords: Glycyl-H-1152 dihydrochloride, supplier, selective, Rho-Associated, Coiled-Coil, Kinases, ROCK, p160ROCK, ROK, Rho-Kinases, Tocris Bioscience, Rho-Kinases Inhibitor products

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