Costunolide

Cat. No. 2483

Costunolide C15H20O2 [553-21-9]

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Chemical Name: (3aS,6E,10E,11aR)-3a,4,5,8,9,11a-Hexahydro-6,10-dimethyl-3-methylene-cyclodeca[b]furan-2(3H)-one

Biological Activity

Inhibitor of human telomerase activity (IC50 = 65 μM in MCF-7 breast cancer cells). Suppresses proliferation and induces apoptosis in a variety of human tumor cell lines. Selectively blocks endothelial cell proliferation induced by VEGF. Inhibits expression of iNOS and IL-1β and disrupts NF-κB activation. Displays anti-inflammatory, antifungal and antiviral properties.

Technical Data

M.Wt:
232.32
Formula:
C15H20O2
Solubility:
Soluble to 50 mM in DMSO and to 50 mM in ethanol
Purity:
>97 %
Storage:
Store at -20°C
CAS No:
553-21-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

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Safety Data Sheet: View Safety Data Sheet

Choi et al (2005) Inhibitory effects of costunolide on the telomerase activity in human breast carcinoma cells. Cancer Lett. 227 153. PMID: 16112418.

Jeong et al (2002) Costunolide, a sesquiterpene lactone from Saussurea lappa, inhibits the VEGFR KDR/Flk-1 signaling pathway. Cancer Lett. 187 129. PMID: 12359360.

Park et al (1996) Syringin 4-O-β-glucoside, a new phenylpropanoid glycoside, and costunolide, a nitric oxide synthase inhibitor, from the stem bark of Magnolia sieboldi. J.Nat.Prod. 59 1128. PMID: 8988596.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for Costunolide include:

Ramirez et al (2013) Biosynthesis of sesquiterpene lactones in pyrethrum (Tanacetum cinerariifolium). PLoS One 8 e65030. PMID: 23741445.

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Keywords: Costunolide, supplier, inhibitors, inhibits, human, telomerase, activity, Polymerases, Protein, Synthesis, RNA, DNA, Tocris Bioscience, Telomerase Inhibitor products

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