Cat. No. 2483
Chemical Name: (3aS,6E,10E,11aR)-3a,4,5,8,9,11a-He
Biological ActivityInhibitor of human telomerase activity (IC50 = 65 μM in MCF-7 breast cancer cells). Suppresses proliferation and induces apoptosis in a variety of human tumor cell lines. Selectively blocks endothelial cell proliferation induced by VEGF. Inhibits expression of iNOS and IL-1β and disrupts NF-κB activation. Displays anti-inflammatory, antifungal and antiviral properties.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Choi et al (2005) Inhibitory effects of costunolide on the telomerase activity in human breast carcinoma cells. Cancer Lett. 227 153. PMID: 16112418.
Jeong et al (2002) Costunolide, a sesquiterpene lactone from Saussurea lappa, inhibits the VEGFR KDR/Flk-1 signaling pathway. Cancer Lett. 187 129. PMID: 12359360.
Park et al (1996) Syringin 4-O-β-glucoside, a new phenylpropanoid glycoside, and costunolide, a nitric oxide synthase inhibitor, from the stem bark of Magnolia sieboldi. J.Nat.Prod. 59 1128. PMID: 8988596.
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Citations are publications that use Tocris products. Selected citations for Costunolide include:
Ramirez et al (2013) Biosynthesis of sesquiterpene lactones in pyrethrum (Tanacetum cinerariifolium). PLoS One 8 e65030. PMID: 23741445.
Liu et al (2011) Reconstitution of the costunolide biosynthetic pathway in yeast and Nicotiana benthamiana. Neuron 6 e23255. PMID: 21858047.
Do you know of a great paper that uses Costunolide from Tocris? If so please let us know.
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Keywords: Costunolide, supplier, inhibitors, inhibits, human, telomerase, activity, Polymerases, Protein, Synthesis, RNA, DNA, Tocris Bioscience, Telomerase Inhibitor products