MG 101

Cat. No. 3358

MG 101 C20H37N3O4 [110044-82-1]

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Alternative Name: Calpain inhibitor-1

Chemical Name: N-Acetyl-L-leucine-L-leucine-L-norleucinal

Biological Activity

Calpain inhibitor (IC50 = 0.09 μM) that activates p53-dependent apoptosis in tumor cell lines. Increases activated p53, p21 and caspase levels and promotes cell cycle arrest through inhibition of cyclin D degradation in vitro. Also attenuates ischemia/reperfusion injury in cardiomyocytes, hepatocytes and renal tubular cells through downregulation of iNOS and COX-2 expression.

Technical Data

M.Wt:
383.53
Formula:
C20H37N3O4
Solubility:
Soluble to 50 mM in DMSO and to 25 mM in ethanol
Storage:
Store at -20°C
CAS No:
110044-82-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Perrin et al (2002) In vitro antioxidant properties of calpain inhibitors: leupeptin and calpain inhibitor-1. Cell Mol.Biol. 48 OL267.

Chatterjee et al (2001) Calpain inhibitor-1 reduces renal ischemia/reperfusion injury in the rat. Kidney Int. 59 2073. PMID: 11380809.

Atencio et al (2000) Calpain inhibitor 1 activates p53-dependent apoptosis in tumor cell lines. Cell Growth Differ. 11 247. PMID: 10845425.

Sherwood et al (1993) In vivo inhibition of cyclin B degradation and induction of cell-cycle arrest in mammalian cells by the neutral cysteine protease inhibitor N-acetylleucylleucylnorleucinal. Proc.Natl.Acad.Sci.USA 90 3353.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for MG 101 include:

Ishizuka et al (2016) PAFR activation of NF-& #954;B p65 or p105 precursor dictates pro-and anti-inflammatory responses during TLR activation in murine macrophages Scientific Reports 6 32092. PMID: 27554194.

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Keywords: MG 101, supplier, Calpain, inhibitors, inhibits, Proteinases, Proteases, MG101, Tocris Bioscience, Calpain Inhibitor products

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