Cat. No. 3358
Alternative Name: Calpain inhibitor-1
Chemical Name: N-Acetyl-L-leucine-L-leucine-L-norl
Biological ActivityCalpain inhibitor (IC50 = 0.09 μM) that activates p53-dependent apoptosis in tumor cell lines. Increases activated p53, p21 and caspase levels and promotes cell cycle arrest through inhibition of cyclin D degradation in vitro. Also attenuates ischemia/reperfusion injury in cardiomyocytes, hepatocytes and renal tubular cells through downregulation of iNOS and COX-2 expression.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Perrin et al (2002) In vitro antioxidant properties of calpain inhibitors: leupeptin and calpain inhibitor-1. Cell Mol.Biol. 48 OL267.
Chatterjee et al (2001) Calpain inhibitor-1 reduces renal ischemia/reperfusion injury in the rat. Kidney Int. 59 2073. PMID: 11380809.
Atencio et al (2000) Calpain inhibitor 1 activates p53-dependent apoptosis in tumor cell lines. Cell Growth Differ. 11 247. PMID: 10845425.
Sherwood et al (1993) In vivo inhibition of cyclin B degradation and induction of cell-cycle arrest in mammalian cells by the neutral cysteine protease inhibitor N-acetylleucylleucylnorleucinal. Proc.Natl.Acad.Sci.USA 90 3353.
If you know of a relevant reference for this product please let us know.
Citations are publications that use Tocris products.
Do you know of a great paper that uses MG 101 from Tocris? If so please let us know.
View Related Products by Product Action
Keywords: MG 101, supplier, Calpain, inhibitors, inhibits, Proteinases, Proteases, MG101, Tocris Bioscience, Calpain Inhibitor products
Find multiple products by catalog number
New Products in this Area
High affinity angiotensin-converting enzyme (ACE) ligandTMI 1
Adam 17 (TACE) and MMP inhibitor; orally bioavailableRitonavir
HIV-1 and HIV-2 protease inhibitorAcetyl Pepstatin
High affinity aspartic protease inhibitor; inhibits HIV-1/2 proteinasesONO 6818
High affinity and selective human neutraphil elastase 1 (HNE1) inhibitor; orally active
November 12 - 16, 2016
San Diego, CA, USA