Staurosporine

Cat. No. 1285

Staurosporine C28H26N4O3 [62996-74-1]

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Chemical Name: [9S-(9α,10β,11β,13α)]-2,3,10,11,12,13-Hexahydro-10-methoxy-9-methyl-11-(methylamino)-9,13-epoxy-1H,9H-diindolo[1,2,3-gh:3',2',1'-lm]pyrrolo[3,4-j][1,7]benzodiazonin-1-one

Biological Activity

Broad spectrum protein kinase inhibitor. Enzymes inhibited include protein kinase C (IC50 = 3 nM), protein kinase A (IC50 = 7 nM), p60v-src tyrosine protein kinase (IC50 = 6 nM) and CaM kinase II (IC50 = 20 nM).

Technical Data

M.Wt:
466.54
Formula:
C28H26N4O3
Solubility:
Soluble to 50 mM in DMSO
Purity:
>98 %
Storage:
Store at +4°C
CAS No:
62996-74-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Yanagihara et al (1991) Staurosporine: an effective inhibitor for Ca2+/calmodulin-dependent protein kinase II. J.Neurochem. 56 294. PMID: 1846174.

Ruegg and Burgess (1989) Staurosporine, K-252 and UCN-01: potent but nonspecific inhibitors of protein kinases. TiPS 10 218. PMID: 2672462.

Tamaoki et al (1986) Staurosporine, a potent inhibitor of phospholipid/Ca2+ dependent protein kinase. Biochem.Biophys.Res.Commun. 135 397. PMID: 3457562.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for Staurosporine include:

Chen et al (2016) Androgen-Sensitized Apoptosis of HPr-1AR Human Prostate Epithelial Cells. Mol Pharmacol 11 e0156145. PMID: 27203692.

Dobson et al (2015) Caffeine Modulates Vesicle Release and Recovery at Cerebellar Parallel Fibre Terminals, Independently of Calcium and Cyclic AMP Signalling. Eur J Neurosci 10 e0125974. PMID: 25933382.

Faulkner et al (2015) FMRP regulates neurogenesis in vivo in Xenopus laevis tadpoles. PLoS One 2 e0055. PMID: 25844398.

Piccart et al (2015) Neurotensin Induces Presynaptic Depression of D2 Dopamine Autoreceptor-Mediated Neurotransmission in Midbrain Dopaminergic Neurons. J Neurosci 35 11144. PMID: 26245975.

Sonamoto et al (2015) Identification of a DYRK1A Inhibitor that Induces Degradation of the Target Kinase using Co-chaperone CDC37 fused with Luciferase nanoKAZ. Eneuro 5 12728. PMID: 26234946.

Barcomb et al (2013) Enzymatic activity of CaMKII is not required for its interaction with the glutamate receptor subunit GluN2B. J Biol Chem 84 834. PMID: 24056996.

Schönbrunn et al (2013) Development of highly potent and selective diaminothiazole inhibitors of cyclin-dependent kinases. J Med Chem 56 3768. PMID: 23600925.

Kawamoto et al (2012) Effect of activation of canonical Wnt signaling by the Wnt-3a protein on the susceptibility of PC12 cells to oxidative and apoptotic insults. PLoS One 45 58. PMID: 22124704.

Kondo et al (2010) Poly(ADP-ribose) polymerase (PARP)-1-independent apoptosis-inducing factor (AIF) release and cell death are induced by eleostearic acid and blocked by α-tocopherol and MEK inhibition. Braz J Med Biol Res 285 13079. PMID: 20177052.

Chen et al (2006) N-myc down-regulated gene 1 modulates the response of term human trophoblasts to hypoxic injury. J Biol Chem 281 2764. PMID: 16314423.

Do you know of a great paper that uses Staurosporine from Tocris? If so please let us know.show all ▼show less ▲

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Keywords: Staurosporine, supplier, Non-Selective, protein, kinases, inhibitors, inhibits, Broad, Spectrum, Tocris Bioscience, Broad Spectrum Protein Kinase Inhibitor Inhibitor products

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