Staurosporine

Cat. No. 1285

Staurosporine C28H26N4O3 [62996-74-1]

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Chemical Name: [9S-(9α,10β,11β,13α)]-2,3,10,11,12,13-Hexahydro-10-methoxy-9-methyl-11-(methylamino)-9,13-epoxy-1H,9H-diindolo[1,2,3-gh:3',2',1'-lm]pyrrolo[3,4-j][1,7]benzodiazonin-1-one

Biological Activity

Broad spectrum protein kinase inhibitor. Enzymes inhibited include protein kinase C (IC50 = 3 nM), protein kinase A (IC50 = 7 nM), p60v-src tyrosine protein kinase (IC50 = 6 nM) and CaM kinase II (IC50 = 20 nM).

Technical Data

M.Wt:
466.54
Formula:
C28H26N4O3
Solubility:
Soluble to 50 mM in DMSO
Purity:
>98 %
Storage:
Store at +4°C
CAS No:
62996-74-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
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Safety Data Sheet: View Safety Data Sheet

Yanagihara et al (1991) Staurosporine: an effective inhibitor for Ca2+/calmodulin-dependent protein kinase II. J.Neurochem. 56 294. PMID: 1846174.

Ruegg and Burgess (1989) Staurosporine, K-252 and UCN-01: potent but nonspecific inhibitors of protein kinases. TiPS 10 218. PMID: 2672462.

Tamaoki et al (1986) Staurosporine, a potent inhibitor of phospholipid/Ca2+ dependent protein kinase. Biochem.Biophys.Res.Commun. 135 397. PMID: 3457562.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for Staurosporine include:

Piccart et al (2015) Neurotensin Induces Presynaptic Depression of D2 Dopamine Autoreceptor-Mediated Neurotransmission in Midbrain Dopaminergic Neurons. J Neurosci 35 11144. PMID: 26245975.

Schönbrunn et al (2013) Development of highly potent and selective diaminothiazole inhibitors of cyclin-dependent kinases. J Med Chem 56 3768. PMID: 23600925.

Chen et al (2006) N-myc down-regulated gene 1 modulates the response of term human trophoblasts to hypoxic injury. J Biol Chem 281 2764. PMID: 16314423.

Do you know of a great paper that uses Staurosporine from Tocris? If so please let us know.

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Keywords: Staurosporine, supplier, Non-Selective, protein, kinases, inhibitors, inhibits, Broad, Spectrum, Tocris Bioscience, Broad Spectrum Protein Kinase Inhibitor Inhibitor products

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