Staurosporine

Cat. No. 1285

Staurosporine C28H26N4O3 [62996-74-1]

Price and Availability

For Staurosporine pricing & availability please select your country from the drop down menu:
Submit
By clicking submit you agree to accept a cookie from Tocris Bioscience. For details, please read our privacy and cookie policy.

Chemical Name: [9S-(9α,10β,11β,13α)]-2,3,10,11,12,13-Hexahydro-10-methoxy-9-methyl-11-(methylamino)-9,13-epoxy-1H,9H-diindolo[1,2,3-gh:3',2',1'-lm]pyrrolo[3,4-j][1,7]benzodiazonin-1-one

Biological Activity

Broad spectrum protein kinase inhibitor. Enzymes inhibited include protein kinase C (IC50 = 3 nM), protein kinase A (IC50 = 7 nM), p60v-src tyrosine protein kinase (IC50 = 6 nM) and CaM kinase II (IC50 = 20 nM).

Technical Data

M.Wt:
466.54
Formula:
C28H26N4O3
Solubility:
Soluble to 50 mM in DMSO
Purity:
>98 %
Storage:
Store at +4°C
CAS No:
62996-74-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Yanagihara et al (1991) Staurosporine: an effective inhibitor for Ca2+/calmodulin-dependent protein kinase II. J.Neurochem. 56 294. PMID: 1846174.

Ruegg and Burgess (1989) Staurosporine, K-252 and UCN-01: potent but nonspecific inhibitors of protein kinases. TiPS 10 218. PMID: 2672462.

Tamaoki et al (1986) Staurosporine, a potent inhibitor of phospholipid/Ca2+ dependent protein kinase. Biochem.Biophys.Res.Commun. 135 397. PMID: 3457562.

If you know of a relevant reference for Staurosporine please let us know.

Citations are publications that use Tocris products. Selected citations for Staurosporine include:

Chen et al (2016) Androgen-Sensitized Apoptosis of HPr-1AR Human Prostate Epithelial Cells. Mol Pharmacol 11 e0156145. PMID: 27203692.

Dobson et al (2015) Caffeine Modulates Vesicle Release and Recovery at Cerebellar Parallel Fibre Terminals, Independently of Calcium and Cyclic AMP Signalling. Eur J Neurosci 10 e0125974. PMID: 25933382.

Faulkner et al (2015) FMRP regulates neurogenesis in vivo in Xenopus laevis tadpoles. PLoS One 2 e0055. PMID: 25844398.

Piccart et al (2015) Neurotensin Induces Presynaptic Depression of D2 Dopamine Autoreceptor-Mediated Neurotransmission in Midbrain Dopaminergic Neurons. J Neurosci 35 11144. PMID: 26245975.

Sonamoto et al (2015) Identification of a DYRK1A Inhibitor that Induces Degradation of the Target Kinase using Co-chaperone CDC37 fused with Luciferase nanoKAZ. Eneuro 5 12728. PMID: 26234946.

Barcomb et al (2013) Enzymatic activity of CaMKII is not required for its interaction with the glutamate receptor subunit GluN2B. J Biol Chem 84 834. PMID: 24056996.

Schönbrunn et al (2013) Development of highly potent and selective diaminothiazole inhibitors of cyclin-dependent kinases. J Med Chem 56 3768. PMID: 23600925.

Kawamoto et al (2012) Effect of activation of canonical Wnt signaling by the Wnt-3a protein on the susceptibility of PC12 cells to oxidative and apoptotic insults. PLoS One 45 58. PMID: 22124704.

Kondo et al (2010) Poly(ADP-ribose) polymerase (PARP)-1-independent apoptosis-inducing factor (AIF) release and cell death are induced by eleostearic acid and blocked by α-tocopherol and MEK inhibition. Braz J Med Biol Res 285 13079. PMID: 20177052.

Chen et al (2006) N-myc down-regulated gene 1 modulates the response of term human trophoblasts to hypoxic injury. J Biol Chem 281 2764. PMID: 16314423.

Do you know of a great paper that uses Staurosporine from Tocris? If so please let us know.show all ▼show less ▲

View Related Products by Target

Keywords: Staurosporine, supplier, Non-Selective, protein, kinases, inhibitors, inhibits, Broad, Spectrum, Tocris Bioscience, Broad Spectrum Protein Kinase Inhibitor Inhibitor products

Quick Order

Find multiple products by catalog number

divider line

Cancer Research Product Guide

Cancer Research Product Guide

Our Cancer Research Guide highlights over 750 products for cancer research. Request copy or view PDF today.

divider line

Kinase Inhibitor Toolbox

80 Kinase inhibitors
pre-dissolved in DMSO

Kinase Inhibitor Toolbox

Includes many of the latest kinase inhibitors to become commercially available. Covers a wide range of kinase targets including EGFR, MAPK and CDK.

divider line

Kinases Product Listing

Kinases Product Listing

Our Kinase listing highlights over 400 products for kinase research. Request copy or view PDF today.

divider line

New Products in this Area

OXSI 2

Potent Syk kinase inhibitor; also inhibits assembly of NLRP3 inflammasomes

STK16-IN-1

Serine/threonine protein kinase 16 (STK16) inhibitor; also inhibits P13Kδ, P13Kγ and mTOR kinases.

AZ PFKFB3 26

Potent and selective PFKFB3 inhibitor

NCL 00017509

Potent and reversible NIMA related kinase 2 (Nek2) inhibitor

XMD 8-87

Potent Ack1/TNK2 inhibitor

SKI 178

Non-lipid sphingosine kinase 1 (SphK1) inhibitor

ML 315 hydrochloride

Inhibitor of Clk and DYRK kinases

Everolimus

mTOR inhibitor;immunosuppressant

PKI (5-24)

High affinity PKA inhibitor

TDZD 8

Selective non-ATP competitive inhibitor of GSK 3β

BI 605906

Selective IKKβ inhibitor

GSK 319347A

Potent and selective IKKε inhibitor

FRAX 597

Potent group I PAK inhibitor

MRT 68921 dihydrochloride

Potent ULK inhibitor; inhibits autophagy

AM 2394

Potent glucokinase activator; orally bioavailable

eCF 309

Potent mTOR inhibitor

PF 3758309 dihydrochloride

Potent PAK4 inhibitor; orally available

AZ Dyrk1B 33

Potent and selective Dyrk1B kinase inhibitor

PF 06409577

Potent and selective allosteric activator of AMPK

Perifosine

PKB/Akt inhibitor; also modulates Kv2.1 current

RAF 265

Raf kinase and VEGFR-2 inhibitor

CZC 25146

Potent LRRK2 inhibitor

Ro 3280

Potent and selective PLK1 inhibitor

RMM 46

MSK/RSK family kinase inhibitor

Sign-up for new product e-alerts
divider line

Bio-Techne Events

26th ISN-ESN Biennal Meeting

26th ISN-ESN Biennal Meeting

August 20 - 24, 2017

Paris , France