Olomoucine

Cat. No. 1284

Olomoucine C15H18N6O [101622-51-9]

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Chemical Name: 6-(Benzylamino)-2-(2-hydroxyethylamino)-9-methylpurine

Biological Activity

Cyclin-dependent kinase inhibitor that competes for the ATP binding site of the kinase. Selectively inhibits cdc2/cyclin B (IC50 = 7 μM), cdk2/cyclin A (IC50 = 7 μM), cdk2/cyclin E (IC50 = 7 μM), cdk/p35 kinase (IC50 = 3 μM)  and ERK1/MAP kinase (IC50 = 25 μM). Arrests human fibroblasts in the G1 phase.

Technical Data

M.Wt:
298.35
Formula:
C15H18N6O
Solubility:
Soluble to 50 mM in ethanol
Storage:
Desiccate at -20°C
CAS No:
101622-51-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Alessi et al (1998) The cyclin-dependent kinase inhibitors olomoucine and roscovitine arrest human fibroblasts in G1 phase by specific inhibition of CDK2 kinase activity. Exp.Cell.Res. 245 8. PMID: 9828096.

Abraham et al (1995) Cellular effects of olomoucine, an inhibitor of cyclin-dependent kinases. Biol.Cell 83 105. PMID: 7549905.

Vesely et al (1994) Inhibition of cyclin-dependent kinases by purine analogues. Eur.J.Biochem. 224 771. PMID: 7925396.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for Olomoucine include:

Cannon et al (2009) Association of luteinizing hormone receptor gene expression with cell cycle progression in granulosa cells. Am J Physiol Endocrinol Metab 296 E1392. PMID: 19293332.

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Keywords: Olomoucine, supplier, Cyclin-dependent, protein, kinases, inhibitors, inhibits, Cdks, Tocris Bioscience, Cyclin-Dependent Protein Kinase Inhibitor products

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