MDL 72222

Cat. No. 0640

MDL 72222 C15H17Cl2NO2 [40796-97-2]

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Chemical Name: Tropanyl 3,5-dichlorobenzoate

Biological Activity

5-HT3 antagonist.

Technical Data

M.Wt:
314.21
Formula:
C15H17Cl2NO2
Solubility:
Soluble to 100 mM in DMSO
Purity:
>99 %
Storage:
Store at RT
CAS No:
40796-97-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Richardson and Engel (1986) The pharmacology and function of 5-HT3 receptors. Trends Neurosci. 9 424.

Fozard (1984) MDL 72222: a potent and highly selective antagonist at neuronal 5-hydroxytryptamine receptors. Naunyn Schmiedebergs Arch.Pharmacol. 326 36. PMID: 6472484.

If you know of a relevant reference for MDL 72222 please let us know.

Citations are publications that use Tocris products. Selected citations for MDL 72222 include:

Bocchio et al (2015) Increased serotonin transporter expression reduces fear and recruitment of parvalbumin interneurons of the amygdala. Neuropsychopharmacology 40 3015. PMID: 26052039.

Woo et al (2007) Neuregulin-1 enhances depolarization-induced GABA release. Neuron 54 599. PMID: 17521572.

Do you know of a great paper that uses MDL 72222 from Tocris? If so please let us know.

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Keywords: MDL 72222, supplier, 5-HT3, antagonists, Serotonin, Receptors, MDL72222, Tocris Bioscience, 5-HT3 Receptor Antagonist products

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5-HT Scientific Review

Written by N. Barnes & J. Neumaler

5-HT Receptors Scientific Review

Our 5-HT review summarizes the serotonin receptor subtypes and highlights their importance in mediating various physiological & pharmacological processes. Request copy or view PDF today.

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