Cat. No. 2476
Chemical Name: (E,E,Z,E)-3-Methyl-7-(4-methylpheny
Biological ActivityInhibitor of activator protein-1 (AP-1) transcription factor activity that displays antitumor effects in vivo. Does not activate transcription from the retinoic acid response element (RARE) and displays no activity at retinoic acid receptors (EC50 > 1 μM for RARα, RARβ, RARγ and RXRα).
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Shiohara et al (1999) Effects of novel RAR- and RXR-selective retinoids on myeloid leukemic proliferation and differentiation in vitro. Blood 93 2057. PMID: 10068679.
Huang et al (1997) Blocking activator protein-1 activity, but not activating retinoic acid response element, is required for the antitumor promotion effect of retinoic acid. Proc.Natl.Acad.Sci.USA 94 5826.
Fanjul et al (1994) A new class of retinoids with selective inhibition of AP-1 inhibits proliferation. Nature 372 107. PMID: 7969403.
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Citations are publications that use Tocris products. Selected citations for SR 11302 include:
Lee et al (2016) Alternative Splicing of Toll-Like Receptor 9 Transcript in Teleost Fish Grouper Is Regulated by NF-& #954;B Signaling via Phosphorylation of the C-Terminal Domain of the RPB1 Subunit of RNA Polymerase II PLoS One 11 e0163415. PMID: 27658294.
Banskota et al (2015) NOX1 to NOX2 switch deactivates AMPK and induces invasive phenotype in colon cancer cells through overexpression of MMP-7. Mol Cancer 14 123. PMID: 26116564.
Chen et al (2015) Adrenomedullin Up-regulates the Expression of Vascular Endothelial Growth Factor in Epithelial Ovarian Carcinoma Cells via JNK/AP-1 Pathway. Sci Rep 25 953. PMID: 26098087.
Huang et al (2015) p38 mitogen-activated protein kinase/activator protein-1 involved in serum deprivation-induced human alkaline ceramidase 2 upregulation. Int J Gynecol Cancer 3 225. PMID: 25798247.
Lee et al (2015) Anti-cancer effect of snake venom toxin through down regulation of AP-1 mediated PRDX6 expression. Oncotarget 6 22139. PMID: 26061816.
Oruqaj et al (2015) Compromised peroxisomes in idiopathic pulmonary fibrosis, a vicious cycle inducing a higher fibrotic response via TGF-β signaling. Proc Natl Acad Sci U S A 112 E2048. PMID: 25848047.
Zheng et al (2015) The AP-1 transcription factor homolog Pf-AP-1 activates transcription of multiple biomineral proteins and potentially participates in Pinctada fucata biomineralization. Invest Ophthalmol Vis Sci 5 14408. PMID: 26404494.
Bakhru et al (2014) BCG vaccine mediated reduction in the MHC-II expression of macrophages and dendritic cells is reversed by activation of Toll-like receptors 7 and 9. Cell Immunol 287 53. PMID: 24384074.
Kim et al (2014) Self-priming determines high type I IFN production by plasmacytoid dendritic cells. Eur J Immunol 44 807. PMID: 24338737.
Mason et al (2014) Effect of prostaglandin E2 on multidrug resistance transporters in human placental cells. Drug Metab Dispos 42 2077. PMID: 25261564.
O'Sullivan et al (2014) Sphingosine 1-phosphate (S1P) induced interleukin-8 (IL-8) release is mediated by S1P receptor 2 and nuclear factor κB in BEAS-2B cells. PLoS One 9 e95566. PMID: 24743449.
Pernet et al (2014) Pseudomonas aeruginosa eradicates Staphylococcus aureus by manipulating the host immunity. Nat Commun 5 5105. PMID: 25290234.
Keasey et al (2013) Inhibition of a novel specific neuroglial integrin signaling pathway increases STAT3-mediated CNTF expression. Cell Commun Signal 11 35. PMID: 23693126.
Vliet et al (2013) Human T cell activation results in extracellular signal-regulated kinase (ERK)-calcineurin-dependent exposure of Tn antigen on the cell surface and binding of the macrophage galactose-type lectin (MGL). J Biol Chem 288 27519. PMID: 23918927.
Ivanova et al (2011) Tamoxifen increases nuclear respiratory factor 1 transcription by activating estrogen receptor beta and AP-1 recruitment to adjacent promoter binding sites. FASEB J 25 1402. PMID: 21233487.
Sethi et al (2011) Transforming growth factor-β induces extracellular matrix protein cross-linking lysyl oxidase (LOX) genes in human trabecular meshwork cells. PLoS One 52 5240. PMID: 21546528.
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Keywords: SR 11302, supplier, inhibitors, inhibits, AP-1, transcription, factors, antitumor, agent, SR11302, Tocris Bioscience, AP-1 Inhibitor products
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