Cat. No. 0786
Alternative Name: MCI-186
Chemical Name: 3-Methyl-1-phenyl-2-pyrazolin-5-one
Biological ActivityA radical scavenger and antioxidant which is able to protect against the effects of ischemia, probably by inhibiting the lipoxygenase system. Protects against MPTP-induced neurotoxicity. Inhibits autophagy.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Galluzzi et al (2017) Pharmacological modulation of autophagy: therapeutic potential and persisting obstacles. Nat.Rev.Drug.Discov. . PMID: 28529316 .
Kawasaki et al (2007) Edaravone (3methyl-1-phenyl-2-pyrazolin-5-one), a radical scavenger, prevents 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced neurotoxicity in the substantia nigra but not the striatum. J.Pharmacol.Exp.Ther. 322 274. PMID: 17429058.
Kawai et al (1997) Effects of a novel free radical scavenger, MC-186, on ischemic brain damage in rat distal middle cerebral artery occlusion model. J.Pharmacol.Exp.Ther. 281 921. PMID: 9152402.
Watanabe et al (1994) Protective effects of MCI-186 on cerebral ischemia: possible involvement of free radical scavenging and antioxidant actions. J.Pharmacol.Exp.Ther. 268 1597. PMID: 8138971.
If you know of a relevant reference for Edaravone please let us know.
Citations are publications that use Tocris products. Selected citations for Edaravone include:
Tsunekawa et al (2013) Enhanced expression of WD repeat-containing protein 35 (WDR35) stimulated by domoic acid in rat hippocampus: involvement of reactive oxygen species generation and p38 mitogen-activated protein kinase activation. Br J Pharmacol 14 4. PMID: 23289926.
Walton et al (2012) Adult neurogenesis transiently generates oxidative stress. PLoS One 7 e35264. PMID: 22558133.
Do you know of a great paper that uses Edaravone from Tocris? If so please let us know.
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Keywords: Edaravone, supplier, Anti-ischemic, antioxidant, free, radical, scavenger, MCI186, Tocris Bioscience, Antioxidant products
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