Edaravone

Cat. No. 0786

Edaravone C10H10N2O [89-25-8]

Price and Availability

For Edaravone pricing & availability please select your country from the drop down menu:
Submit
By clicking submit you agree to accept a cookie from Tocris Bioscience. For details, please read our privacy and cookie policy.

Alternative Name: MCI-186

Chemical Name: 3-Methyl-1-phenyl-2-pyrazolin-5-one

Biological Activity

A radical scavenger and antioxidant which is able to protect against the effects of ischemia, probably by inhibiting the lipoxygenase system. Protects against MPTP-induced neurotoxicity. Inhibits autophagy.

Technical Data

M.Wt:
174.2
Formula:
C10H10N2O
Solubility:
Soluble to 100 mM in DMSO
Purity:
>99 %
Storage:
Store at RT
CAS No:
89-25-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Galluzzi et al (2017) Pharmacological modulation of autophagy: therapeutic potential and persisting obstacles. Nat.Rev.Drug.Discov. . PMID: 28529316 .

Kawasaki et al (2007) Edaravone (3methyl-1-phenyl-2-pyrazolin-5-one), a radical scavenger, prevents 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced neurotoxicity in the substantia nigra but not the striatum. J.Pharmacol.Exp.Ther. 322 274. PMID: 17429058.

Kawai et al (1997) Effects of a novel free radical scavenger, MC-186, on ischemic brain damage in rat distal middle cerebral artery occlusion model. J.Pharmacol.Exp.Ther. 281 921. PMID: 9152402.

Watanabe et al (1994) Protective effects of MCI-186 on cerebral ischemia: possible involvement of free radical scavenging and antioxidant actions. J.Pharmacol.Exp.Ther. 268 1597. PMID: 8138971.

If you know of a relevant reference for Edaravone please let us know.

Citations are publications that use Tocris products. Selected citations for Edaravone include:

Tsunekawa et al (2013) Enhanced expression of WD repeat-containing protein 35 (WDR35) stimulated by domoic acid in rat hippocampus: involvement of reactive oxygen species generation and p38 mitogen-activated protein kinase activation. Br J Pharmacol 14 4. PMID: 23289926.

Walton et al (2012) Adult neurogenesis transiently generates oxidative stress. PLoS One 7 e35264. PMID: 22558133.

Do you know of a great paper that uses Edaravone from Tocris? If so please let us know.

View Related Products by Target

View Related Products by Product Action

Keywords: Edaravone, supplier, Anti-ischemic, antioxidant, free, radical, scavenger, MCI186, Tocris Bioscience, Antioxidant products

Quick Order

Find multiple products by catalog number

divider line

New Product Guide

Spring/Summer 2017

New Product Guide (Spring/Summer 2017)

Our New Product guide highlights over 130 new products added in the first half of 2017. View PDF today.

divider line

New Products in this Area

NITD 008

Antiviral; selective flavivirus inhibitor

Nanchangmycin

Antiviral; active against Zika, West Nile and dengue viruses

25-Hydroxycholesterol

Antiviral; also α-crystallin (cryAB) chaperone

Filipin III

Polyene antibiotic; inhibits formation of pathological isoform of prion protein

Sign-up for new product e-alerts
divider line

LinkedIn Updates

Follow Tocris on LinkedIn

Follow us on LinkedIn!

Visit our LinkedIn page for the latest Tocris news, events and updates.