MAP4

Cat. No. 0711

MAP4 C5H12NO5P [157381-42-5]

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Chemical Name: (S)-2-Amino-2-methyl-4-phosphonobutanoic acid

Biological Activity

Selective group III metabotropic glutamate receptor antagonist in some electrophysiological systems. Group II/group III agonist in certain neurochemical systems.

Technical Data

M.Wt:
197.13
Formula:
C5H12NO5P
Solubility:
Soluble to 100 mM in water
Purity:
>96 %
Storage:
Store at RT
CAS No:
157381-42-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
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Safety Data Sheet: View Safety Data Sheet

Kemp et al (1996) Agonists of cyclic AMP-coupled metabotropic glutamate receptors in adult rat cortical slices. Eur.J.Pharmacol. 309 79. PMID: 8864697.

Sekiyama et al (1996) Structure-activity relationships of new agonists and antagonists of different metabotropic glutamate receptor subtypes. Br.J.Pharmacol. 117 1493. PMID: 8730745.

Salt and Eaton (1995) Distinct presynaptic metabotropic receptors for L-AP4 and CCGl on GABAergic terminals: pharmacological evidence using novel α-methyl derivative mGluR antagonists, MAP4 and MCCG, in the rat thalamus in vivo. Neuroscience 65 5. PMID: 7753406.

Jane et al (1994) Actions of two new sub-type selective metabotropic glutamate receptor antagonists in the neonatal rat spinal cord. Br.J.Pharmacol. 112 809. PMID: 7921606.

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Keywords: MAP4, supplier, Potent, group, II, mGlur, agonists, specific, III, antagonists, Selective, potent, Group, Receptors, mGlu2, mGlu3, mGluR2, mGluR3, Glutamate, Metabotropic, mGlu4, mGluR4, mGlu6, mGluR6, mGlu7, mGluR7, mGlu8, mGlkuR8, Tocris Bioscience, Glutamate (Metabotropic) Group II Receptor Agonist products

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