Cat. No. 0711
Chemical Name: (S)-2-Amino-2-methyl-4-phosphonobut
Biological ActivitySelective group III metabotropic glutamate receptor antagonist in some electrophysiological systems. Group II/group III agonist in certain neurochemical systems.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Kemp et al (1996) Agonists of cyclic AMP-coupled metabotropic glutamate receptors in adult rat cortical slices. Eur.J.Pharmacol. 309 79. PMID: 8864697.
Sekiyama et al (1996) Structure-activity relationships of new agonists and antagonists of different metabotropic glutamate receptor subtypes. Br.J.Pharmacol. 117 1493. PMID: 8730745.
Salt and Eaton (1995) Distinct presynaptic metabotropic receptors for L-AP4 and CCGl on GABAergic terminals: pharmacological evidence using novel α-methyl derivative mGluR antagonists, MAP4 and MCCG, in the rat thalamus in vivo. Neuroscience 65 5. PMID: 7753406.
Jane et al (1994) Actions of two new sub-type selective metabotropic glutamate receptor antagonists in the neonatal rat spinal cord. Br.J.Pharmacol. 112 809. PMID: 7921606.
If you know of a relevant reference for MAP4 please let us know.
Citations are publications that use Tocris products. Selected citations for MAP4 include:
Piet et al (2004) Physiological contribution of the astrocytic environment of neurons to intersynaptic crosstalk. J Neurosci 101 2151. PMID: 14766975.
Do you know of a great paper that uses MAP4 from Tocris? If so please let us know.
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Keywords: MAP4, supplier, Potent, group, II, mGlur, agonists, specific, III, antagonists, Selective, potent, Group, Receptors, mGlu2, mGlu3, mGluR2, mGluR3, Glutamate, Metabotropic, mGlu4, mGluR4, mGlu6, mGluR6, mGlu7, mGluR7, mGlu8, mGlkuR8, Tocris Bioscience, Glutamate (Metabotropic) Group II Receptor Agonist products