Luzindole

Cat. No. 0877

Luzindole C19H20N2O [117946-91-5]

Price and Availability

For Luzindole pricing & availability please select your country from the drop down menu:
Submit
By clicking submit you agree to accept a cookie from Tocris Bioscience. For details, please read our privacy and cookie policy.

Chemical Name: N-Acetyl-2-benzyltryptamine

Biological Activity

Melatonin antagonist.

Technical Data

M.Wt:
292.38
Formula:
C19H20N2O
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:
>99 %
Storage:
Store at -20°C
CAS No:
117946-91-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Dubocovich (1995) Melatonin receptors: are there multiple subtypes? TiPS 16 50. PMID: 7762083.

Dubocovich et al (1990) Anti-depressant-like activity of the melatonin receptor antagonist, luzindole (N-0774), in mouse behavioural despair test. Eur.J.Pharmacol. 182 313. PMID: 2168835.

Dubocovich (1988) Luzindole (N-0774): a novel melatonin receptor antagonist. J.Pharmacol.Exp.Ther. 246 902. PMID: 2843633.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for Luzindole include:

Letra-Vilela et al (2016) Distinct roles of N-acetyl and 5-methoxy groups in the antiproliferative and neuroprotective effects of melatonin Molecular and Cellular Endocrinology 434 238. PMID: 27402602.

Chen et al (2014) Antinociceptive effects of novel melatonin receptor agonists in mouse models of abdominal pain. J Clin Invest 20 1298. PMID: 24574803.

Legros et al (2014) Melatonin MT1 and MT2 receptors display different molecular pharmacologies only in the G-protein coupled state. Br J Pharmacol 171 186. PMID: 24117008.

Nishiyama and Hirai (2014) The melatonin agonist ramelteon induces duration-dependent clock gene expression through cAMP signaling in pancreatic INS-1 β-cells. PLoS One 9 e102073. PMID: 25013953.

Muxel et al (2013) NF-κB drives the synthesis of melatonin in RAW 264.7 macrophages by inducing the transcription of the arylalkylamine-N-acetyltransferase (AA-NAT) gene. Endocrinology 7 e52010. PMID: 23284853.

Kojima et al (2011) Melatonin inhibits tachykinin NK2 receptor-triggered 5-HT release from guinea pig isolated colonic mucosa. Br J Pharmacol 162 1179. PMID: 21091649.

Tunstall et al (2011) MT2 receptors mediate the inhibitory effects of melatonin on nitric oxide-induced relaxation of porcine isolated coronary arteries. J Neuroinflammation 336 127. PMID: 20959363.

Savinainen et al (2005) Identification of WIN55212-3 as a competitive neutral antagonist of the human cannabinoid CB2 receptor. Br J Pharmacol 145 636. PMID: 15852035.

Roy et al (2001) Cyclical regulation of GnRH gene expression in GT1-7 GnRH-secreting neurons by melatonin. World J Gastroenterol 142 4711. PMID: 11606436.

Sjöblom et al (2001) Peripheral melatonin mediates neural stimulation of duodenal mucosal bicarbonate secretion. J Pharmacol Exp Ther 108 625. PMID: 11518737.

Do you know of a great paper that uses Luzindole from Tocris? If so please let us know.show all ▼show less ▲

View Related Products by Product Action

Keywords: Luzindole, supplier, Competitive, melatonin, MT1, MT2, antagonists, Receptors, Tocris Bioscience, Melatonin Receptor Antagonist products

Quick Order

Find multiple products by catalog number

divider line

GPCR Product Listing

GPCR Product Listing

Highlights over 450 products for GPCRs. Request copy or view PDF today.

divider line

New Products in this Area

ZQ 16

Selective GPR84 agonist

IHR-Cy3

Potent fluorescent Smo antagonist

Ro 6842262

Potent LPA1 antagonist

AMG 853

Potent dual CRTH2 and prostaglandin D2 (PGD2) receptor antagonist

AM 4668

Potent FFA1 (GPR40) agonist

CATPB

FFA2 antagonist/inverse agonist

Oleanolic acid

Selective GPBA receptor (TGR5) partial agonist

PPTN hydrochloride

High affinity and selective P2Y14 antagonist

Itraconazole

SMO antagonist; acts at different binding site to cyclopamine (Cat No. 1623)

Sign-up for new product e-alerts
divider line

Bio-Techne Events

ASN 2017

ASN 2017

March 18 - 22, 2017

Little Rock, ARK, USA