Luzindole

Cat. No. 0877

Luzindole C19H20N2O [117946-91-5]

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Chemical Name: N-Acetyl-2-benzyltryptamine

Biological Activity

Melatonin antagonist.

Technical Data

M.Wt:
292.38
Formula:
C19H20N2O
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:
>99 %
Storage:
Store at -20°C
CAS No:
117946-91-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Dubocovich (1995) Melatonin receptors: are there multiple subtypes? TiPS 16 50. PMID: 7762083.

Dubocovich et al (1990) Anti-depressant-like activity of the melatonin receptor antagonist, luzindole (N-0774), in mouse behavioural despair test. Eur.J.Pharmacol. 182 313. PMID: 2168835.

Dubocovich (1988) Luzindole (N-0774): a novel melatonin receptor antagonist. J.Pharmacol.Exp.Ther. 246 902. PMID: 2843633.

If you know of a relevant reference for Luzindole please let us know.

Citations are publications that use Tocris products. Selected citations for Luzindole include:

Letra-Vilela et al (2016) Distinct roles of N-acetyl and 5-methoxy groups in the antiproliferative and neuroprotective effects of melatonin Molecular and Cellular Endocrinology 434 238. PMID: 27402602.

Chen et al (2014) Antinociceptive effects of novel melatonin receptor agonists in mouse models of abdominal pain. J Clin Invest 20 1298. PMID: 24574803.

Legros et al (2014) Melatonin MT1 and MT2 receptors display different molecular pharmacologies only in the G-protein coupled state. Br J Pharmacol 171 186. PMID: 24117008.

Nishiyama and Hirai (2014) The melatonin agonist ramelteon induces duration-dependent clock gene expression through cAMP signaling in pancreatic INS-1 β-cells. PLoS One 9 e102073. PMID: 25013953.

Muxel et al (2013) NF-κB drives the synthesis of melatonin in RAW 264.7 macrophages by inducing the transcription of the arylalkylamine-N-acetyltransferase (AA-NAT) gene. Endocrinology 7 e52010. PMID: 23284853.

Kojima et al (2011) Melatonin inhibits tachykinin NK2 receptor-triggered 5-HT release from guinea pig isolated colonic mucosa. Br J Pharmacol 162 1179. PMID: 21091649.

Tunstall et al (2011) MT2 receptors mediate the inhibitory effects of melatonin on nitric oxide-induced relaxation of porcine isolated coronary arteries. J Neuroinflammation 336 127. PMID: 20959363.

Savinainen et al (2005) Identification of WIN55212-3 as a competitive neutral antagonist of the human cannabinoid CB2 receptor. Br J Pharmacol 145 636. PMID: 15852035.

Roy et al (2001) Cyclical regulation of GnRH gene expression in GT1-7 GnRH-secreting neurons by melatonin. World J Gastroenterol 142 4711. PMID: 11606436.

Sjöblom et al (2001) Peripheral melatonin mediates neural stimulation of duodenal mucosal bicarbonate secretion. J Pharmacol Exp Ther 108 625. PMID: 11518737.

Do you know of a great paper that uses Luzindole from Tocris? If so please let us know.show all ▼show less ▲

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Keywords: Luzindole, supplier, Competitive, melatonin, MT1, MT2, antagonists, Receptors, Tocris Bioscience, Melatonin Receptor Antagonist products

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