D-myo-Inositol-1,3,4,5-tetrakisphosphate, octapotassium salt

Cat. No. 1420

D-myo-Inositol-1,3,4,5-tetrakisphosphate, octapotassium salt C6H8O18P4.K8 [145843-69-2]

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Biological Activity

Phosphorylation product of inositol 1,4,5-trisphosphate (Ins (1,4,5)P3). Potent inhibitor of Ins (1,4,5)P3 5-phosphatase (IC50 ~150 nM); facilitates Ca2+ influx by sensitizing Ins (1,4,5)P3-mediated activation of ICRAC. At higher concentrations, acts as an inhibitor of Ins (1,4,5)P3 receptors.

Technical Data

M.Wt:
804.73
Formula:
C6H8O18P4.K8
Solubility:
Soluble in water
Purity:
>98 %
Storage:
Desiccate at -20°C
CAS No:
145843-69-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Hermosura et al (2000) InsP4 facilitates store-operated calcium influx by inhibition of InsP3 5-phosphatase. Nature 408 735. PMID: 11130077.

Cullen et al (1998) Bridging the GAP in inositol 1,3,4,5-tetrakisphosphate signalling. Biochim.Biophys.Acta 1436 35. PMID: 9838034.

Balla et al (1991) Agonist-induced calcium signaling is impaired in fibroblasts overproducing inositol 1,3,4,5-tetrakisphosphate. J.Biol.Chem. 266 24719. PMID: 1662215.

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Keywords: D-myo-Inositol-1,3,4,5-tetrakisphosphate, octapotassium salt, supplier, Potent, inhibitors, inhibits, Ins145P3, 5-phosphatase, Tocris Bioscience, Inositol Phosphatase Inhibitor products

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