Naloxone benzoylhydrazone

Cat. No. 1419

Naloxone benzoylhydrazone C26H27N3O4 [119630-94-3]

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Alternative Name: NalBzOH

Chemical Name: [(5α)-4,5-Epoxy-3,14-dihydroxy-17-(2-propenyl)morphinan-6-ylidene] benzoic acid hydrazide

Biological Activity

Mixed opioid receptor agonist/antagonist. Acts as a potent and full agonist at κ, a partial agonist at μ and δ opioid receptors (pEC50 values are 9.45, 8.74 and 8.61 in a cAMP assay, 9.70, 8.59 and 8.49 in a [35S]GTPγS binding assay respectively). Fails to exert agonist effects at NOP receptors and antagonizes agonist-induced NOP activation. Stimulates κ-, μ- and δ-mediated analgesia and blocks NOP-induced supraspinal nociception.

Technical Data

M.Wt:
445.52
Formula:
C26H27N3O4
Solubility:
Soluble to 50 mM in DMSO
Purity:
>99 %
Storage:
Desiccate at +4°C
CAS No:
119630-94-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Connor and Kitchen (2006) Has the sun set on κ3-opioid receptors? Br.J.Pharmacol 147 349. PMID: 16402044.

Olianas et al (2006) Agonist activity of naloxone benzoylhydrazone at recombinant and native opioid receptors. Br.J.Pharmacol. 147 360. PMID: 16402046.

Gistrak et al (1989) Pharmacological actions of a novel mixed opiate agonist/antagonist: naloxone benzoylhydrazone J.Pharmacol.Exp.Ther. 251 469. PMID: 2553921.

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Keywords: Naloxone benzoylhydrazone, supplier, κ-opioid, kappa-opioid, agonists, partial, μ-opioid, mu-opioid, δ-opioid, delta-opioid, antagonists, NOP, Opioids, Receptors, Tocris Bioscience, Miscellaneous Opioid products

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