Resveratrol

Cat. No. 1418

Resveratrol C14H12O3 [501-36-0]

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Chemical Name: 5-[(1E)-2-(4-Hydroxyphenyl)ethenyl]-1,3,benzenediol

Biological Activity

A phytoestrogen with antitumor, antioxidant, antiplatelet, anti-inflammatory and antifungal effects. Inhibits cytochrome P450 1A1 (IC50 = 23 μM) and displays mixed agonist/antagonist actions at ERα and ERβ estrogen receptors. Converted into the anticancer agent piceatannol (Cat. No. 1554) by cytochrome P450 1B1.

Technical Data

M.Wt:
228.25
Formula:
C14H12O3
Solubility:
Soluble to 100 mM in ethanol and to 100 mM in DMSO
Purity:
>98 %
Storage:
Desiccate at +4°C
CAS No:
501-36-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Certificate of Analysis / Product Datasheet
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Baptista et al (2013) Regulation of histone H2A.Z exprsesion is mediated by sirtuin 1 in prostate cancer. Oncotarget 4 1673. PMID: 24127549.

Baur and Sinclair (2006) Therapeutic potential of resveratrol: the in vivo evidence. Nat.Rev.Drug Discov. 5 493. PMID: 16732220.

Bowers et al (2000) Resveratrol acts as a mixed agonist/antagonist for estrogen receptors α and β. Endocrinology 141 3657. PMID: 11014220.

Fremont (2000) Biological effects of resveratrol. Life Sci. 66 663. PMID: 10680575.

Chun et al (1999) Resveratrol is a selective human cytochrome P450 1A1 inhibitor. Biochem.Biophys.Res.Commun. 262 20. PMID: 10448061.

Kimura et al (1985) Effects of stilbenes on arachidonate metabolism in leukocytes. Biochim.Biophys.Acta 834 275. PMID: 3922423.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for Resveratrol include:

Meftahi et al (2015) Suppressive Effects of Resveratrol Treatment on The Intrinsic Evoked Excitability of CA1 Pyramidal Neurons. Evid Based Complement Alternat Med 17 532. PMID: 26464825.

Chen et al (2014) A critical role for interferon regulatory factor 9 in cerebral ischemic stroke. J Neurosci 34 11897. PMID: 25186738.

Jiang and Zsombok (2014) Regulation of neurons in the dorsal motor nucleus of the vagus by SIRT1. Front Neurosci 7 270. PMID: 24454277.

Rojas et al (2014) Astrocytes expressing mutant SOD1 and TDP43 trigger motoneuron death that is mediated via sodium channels and nitroxidative stress. Front Cell Neurosci 8 24. PMID: 24570655.

Wang et al (2013) Active Constituents from Liriope platyphylla Root against Cancer Growth In Vitro. Cancer Res 2013 857929. PMID: 23762164.

Pacholec et al (2010) SRT1720, SRT2183, SRT1460, and resveratrol are not direct activators of SIRT1. J Biol Chem 285 8340. PMID: 20061378.

Ohshiro et al (2007) Identifying the estrogen receptor coactivator PELP1 in autophagosomes. Br J Pharmacol 67 8164. PMID: 17804729.

Do you know of a great paper that uses Resveratrol from Tocris? If so please let us know.show all ▼show less ▲

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Keywords: Resveratrol, supplier, Antitumor, anti-oxidant, agent, Cyclooxygenase, inhibitors, inhibits, COX, Oxygenases, Oxidases, Tocris Bioscience, Cyclooxygenase Inhibitor products

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