ER 27319 maleate
Cat. No. 2471
Chemical Name: 10-(3-Aminopropyl)-3,4-dimethyl-9(1
Biological ActivitySelective inhibitor of Syk kinase. Inhibits tyrosine phosphorylation of Syk initiated by the engagement of FcεRI in rat and human mast cells. Results in the abrogation of degranulation, TNF-α production (IC50 = 10 μM) and other related signaling events.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Luskova and Draber (2004) Modulation of the Fcε receptor I signaling by tyrosine kinase inhibitors: search for therapeutic targets of inflammatory and allergy diseases. Curr.Pharm.Des. 10 1727. PMID: 15180535.
Moriya et al (1997) ER-27319, an acridone-related compound, inhibits release of antigen-induced allergic mediators from mast cells by selective inhibition of Fce receptor I-mediated activation of Syk. Proc.Natl.Acad.Sci.USA 94 12539.
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Citations are publications that use Tocris products. Selected citations for ER 27319 maleate include:
Ng et al (2008) Receptor-independent, direct membrane binding leads to cell-surface lipid sorting and Syk kinase activation in dendritic cells. Immunity 29 807. PMID: 18993083.
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Keywords: ER 27319 maleate, supplier, Selective, Syk, kinases, inhibitors, inhibits, TNF-α, TNF-alpha, production, Interleukins, Tumor, Necrosis, Factor-α, Factor-alpha, Cytokines, ER27319, maleate, Tocris Bioscience, Syk Kinase Inhibitor products
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