Cat. No. 2470

Nimesulide C13H12N2O5S [51803-78-2]

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Alternative Names: Flogovital, Aulin

Chemical Name: N-(4-Nitro-2-phenoxyphenyl)methanesulfonamide

Biological Activity

Selective, orally active cyclooxygenase-2 (COX-2) inhibitor. Produces potent analgesic, anti-inflammatory and antipyretic activities in vivo. Reported to produce fewer gastrointestinal side effects than standard NSAIDs.  .

Technical Data

Soluble to 100 mM in DMSO and to 25 mM in ethanol
>99 %
Store at +4°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

Cullen et al (1998) Selective cyclooxygenase-2 inhibition by nimesulide in man. J.Pharmacol.Exp.Ther. 287 578. PMID: 9808683.

Famaey (1997) In vitro and in vivo pharmacological evidence of selective cyclooxygenase-2 inhibition by nimesulide: an overview. Inflamm.Res. 46 437. PMID: 9427063.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for Nimesulide include:

Baranowska-Kuczko et al (2014) Mechanisms of endothelium-dependent relaxation evoked by anandamide in isolated human pulmonary arteries. J Neuroimmune Pharmacol 387 477. PMID: 24682422.

Anneken et al (2013) MDMA increases glutamate release and reduces parvalbumin-positive GABAergic cells in the dorsal hippocampus of the rat: role of cyclooxygenase. Nat Commun 8 58. PMID: 23179355.

Staniaszek et al (2010) Effects of COX-2 inhibition on spinal nociception: the role of endocannabinoids. Br J Pharmacol 160 669. PMID: 20590570.

Do you know of a great paper that uses Nimesulide from Tocris? If so please let us know.

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Keywords: Nimesulide, supplier, Cyclooxygenase-2, COX-2, inhibitors, inhibits, Cyclooxygenase, Oxygenases, Oxidases, Tocris Bioscience, Cyclooxygenase Inhibitor products

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