IBC 293

Cat. No. 2469

IBC 293 C10H11N3O2 [306935-41-1]

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Chemical Name: 1-(1-Methylethyl)-1H-benzotriazole-5-carboxylic acid

Biological Activity

Highly selective agonist for GPR109B (HM74), human orphan G-protein-coupled receptor expressed in adipocytes. Selective for GPR109B over niacin receptor GPR109A (HM74A); EC50 values are 400 nM and > 1 μM respectively. Inhibits isoproterenol-stimulated lipolysis in vitro in isolated human adipocytes.

Technical Data

M.Wt:
205.22
Formula:
C10H11N3O2
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:
>99 %
Storage:
Store at RT
CAS No:
306935-41-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Semple et al (2006) 1-Alkyl-benzotriazole-5-carboxylic acids are highly selective agonists of the human orphan G-protein-coupled receptor GPR109b. J.Med.Chem. 49 1227. PMID: 16480258.

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Keywords: IBC 293, supplier, Selective, agonists, GPR109B, HM74, receptors, Antilipolytic, GPR109, Receptors, Nicotinic, Acid, IBC293, Tocris Bioscience, Hydroxycarboxylic Acid Receptor Agonist products

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