Cat. No. 2469
Chemical Name: 1-(1-Methylethyl)-1H-benzotriazole-
Biological ActivityHighly selective agonist for GPR109B (HM74), human orphan G-protein-coupled receptor expressed in adipocytes. Selective for GPR109B over niacin receptor GPR109A (HM74A); EC50 values are 400 nM and > 1 μM respectively. Inhibits isoproterenol-stimulated lipolysis in vitro in isolated human adipocytes.
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All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
Semple et al (2006) 1-Alkyl-benzotriazole-5-carboxylic acids are highly selective agonists of the human orphan G-protein-coupled receptor GPR109b. J.Med.Chem. 49 1227. PMID: 16480258.
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Keywords: IBC 293, supplier, Selective, agonists, GPR109B, HM74, receptors, Antilipolytic, GPR109, Receptors, Nicotinic, Acid, IBC293, Tocris Bioscience, Hydroxycarboxylic Acid Receptor Agonist products
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