Cat. No. 0868

L-732,138 C22H18F6N2O3 [148451-96-1]

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Chemical Name: N-Acetyl-L-tryptophan 3,5-bis(trifluoromethyl)benzyl ester

Biological Activity

Potent and highly selective competitive tachykinin NK1 receptor antagonist (IC50 = 2.3 nM).

Licensing Information

Sold with the permission of Merck Sharp and Dohme Ltd.

Technical Data

Soluble to 100 mM in ethanol and to 100 mM in DMSO
>98 %
Store at RT

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Kuo et al (1998) Lipopolysaccharide enhances neurogenic plasma exudation in guinea-pig airways. Br.J.Pharmacol. 125 711. PMID: 9831906.

Cascieri et al (1994) Characterization of the interaction of N-acyl-L-tryptophan benzyl ester neurokinin antagonists with the human neurokinin-1 receptor. J.Biol.Chem. 269 6587. PMID: 7509807.

MacLeod et al (1994) Identification of L-tryptophan derivatives with potent and selective antagonist activity at the NK1 receptor. J.Med.Chem. 37 1269. PMID: 7513763.

MacLeod et al (1993) N-Acyl-L-tryptophan benzyl esters: potent substance P receptor antagonists. J.Med.Chem. 36 2044. PMID: 8393115.

If you know of a relevant reference for L-732,138 please let us know.

Citations are publications that use Tocris products. Selected citations for L-732,138 include:

Li et al (2013) Neurotransmitter substance P mediates pancreatic cancer perineural invasion via NK-1R in cancer cells. J Neurosci 11 294. PMID: 23345604.

Do you know of a great paper that uses L-732,138 from Tocris? If so please let us know.

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Keywords: L-732,138, supplier, Potent, selective, NK1, antagonists, Tachykinin, Receptors, Neurokinin, L732138, merck, Tocris Bioscience, NK1 Receptor Antagonist products

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