L-732,138

Cat. No. 0868

L-732,138 C22H18F6N2O3 [148451-96-1]

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Chemical Name: N-Acetyl-L-tryptophan 3,5-bis(trifluoromethyl)benzyl ester

Biological Activity

Potent and highly selective competitive tachykinin NK1 receptor antagonist (IC50 = 2.3 nM).

Licensing Information

Sold with the permission of Merck Sharp and Dohme Ltd.

Technical Data

M.Wt:
472.39
Formula:
C22H18F6N2O3
Solubility:
Soluble to 100 mM in ethanol and to 100 mM in DMSO
Purity:
>98 %
Storage:
Store at RT
CAS No:
148451-96-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
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Safety Data Sheet: View Safety Data Sheet

Kuo et al (1998) Lipopolysaccharide enhances neurogenic plasma exudation in guinea-pig airways. Br.J.Pharmacol. 125 711. PMID: 9831906.

Cascieri et al (1994) Characterization of the interaction of N-acyl-L-tryptophan benzyl ester neurokinin antagonists with the human neurokinin-1 receptor. J.Biol.Chem. 269 6587. PMID: 7509807.

MacLeod et al (1994) Identification of L-tryptophan derivatives with potent and selective antagonist activity at the NK1 receptor. J.Med.Chem. 37 1269. PMID: 7513763.

MacLeod et al (1993) N-Acyl-L-tryptophan benzyl esters: potent substance P receptor antagonists. J.Med.Chem. 36 2044. PMID: 8393115.

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Keywords: L-732,138, supplier, Potent, selective, NK1, antagonists, Tachykinin, Receptors, Neurokinin, L732138, merck, Tocris Bioscience, NK1 Receptor Antagonist products

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