Cat. No. 0705
Chemical Name: 7-Chloro-3-(cyclopropylcarbonyl)-4-
Biological ActivityAn antagonist at the glycine-NMDA site (IC50 = 420 nM). Also a potent systemic anticonvulsant.
Licensing InformationSold with the permission of Merck Sharp and Dohme Ltd.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Stone (2000) Development and therapeutic potential of kynurenic acid and kynurenine derivatives for neuroprotection. TiPS 21 149. PMID: 10740291.
Rowley et al (1993) 3-Acyl-4-hydroxyquinolin-2(1H)-ones. Systemically active anticonvulsants acting by antagonism at the glycine site of the NMDA receptor complex. J.Med.Chem. 36 3386. PMID: 8230129.
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Keywords: L-701,252, supplier, NMDA, antagonists, glycine, site, Glutamate, Receptors, N-Methyl-D-Aspartate, iGluR, Ionotropic, anticonvulsant, L701252, merck, Tocris Bioscience, NMDA Receptor Antagonist products
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