CGS 20625

Cat. No. 2467

CGS 20625 C18H19N3O2 [111205-55-1]

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Chemical Name: 5,6,7,8,9,10-Hexahydro-2-(4-methoxyphenyl)cyclohepta[b]pyrazolo[3,4-d]pyridin-3(2H)-one

Biological Activity

Selective, partial agonist for the benzodiazepine binding site of the GABAA receptor. Potently inhibits [3H]-flunitrazepam binding to central benzodiazepine receptors (IC50 = 1.3 nM) and displays weak affinity for peripheral benzodiazepine (IC50 = 0.68 - 2.25 μM) and GABA binding sites (IC50 > 10000 μM). Displays anxiolytic activity in vivo following oral administration. .

Technical Data

Soluble to 100 mM in DMSO and to 25 mM in ethanol
>99 %
Store at +4°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Jarvis et al (1990) CGS 20625, a novel pyrazolopyridine with selective anxiolytic activity. Prog.Clin.Biol.Res. 361 477. PMID: 1981266.

Williams et al (1989) CGS 20625, a novel pyrazolopyridine anxiolytic. J.Pharmacol.Exp.Ther. 248 89. PMID: 2563294.

Bennett (1987) Pharmacology of the pyrazolo-type compounds: agonist, antagonist and inverse agonist actions. Physiol.Behav. 41 241. PMID: 2893398.

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Keywords: CGS 20625, supplier, Selective, central, benzodiazepine, receptor, partial, agonists, GABAA, Receptors, CGS20625, Tocris Bioscience, GABAA Receptor Benzodiazepine products

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