UK 14,304 tartrate

Cat. No. 2466

UK 14,304 tartrate C11H10BrN5.C4H6O6 [70359-46-5]

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Chemical Name: 5-Bromo-6-(2-imidazolin-2-ylamino)quinoxaline tartrate

Biological Activity

Water-soluble form of UK 14,304 (Cat. No. 0425). Full α2 adrenergic agonist. Centrally active following systemic administration in vivo.

Technical Data

M.Wt:
442.23
Formula:
C11H10BrN5.C4H6O6
Solubility:
Soluble to 50 mM in water
Purity:
>99 %
Storage:
Desiccate at RT
CAS No:
70359-46-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

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Chopin et al (1999) Effects of alpha-2 adrenoceptor agonists and antagonists on circling behavior in rats with unilateral 6-hydroxydopamine lesions of the nigrostriatal pathway. J.Pharmacol.Exp.Ther. 288 798. PMID: 9918591.

Macdonald et al (1997) Gene targeting - homing in on α2-adrenoceptor-subtype function. TiPS 18 211. PMID: 9227000.

Andorn et al (1988) Specific [3H]UK-14,304 binding in human cortex occurs at multiple high affinity states with α2-adrenergic selectivity and different affinities for GTP. Life Sci. 43 1805. PMID: 2904634.

Cambridge (1981) UK-14,304, a potent and selective alpha2-gonist for the characterisation of alpha-adrenoceptor subtypes. Eur.J.Pharmacol. 72 413. PMID: 6115759.

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