SDZ WAG 994

Cat. No. 2465

SDZ WAG 994 C17H25N5O4 [130714-47-5]

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Chemical Name: N-Cyclohexyl-2'-O-methyladenosine

Biological Activity

Potent and selective A1 adenosine receptor agonist (Ki values are 23, > 10000 and 25000 nM for A1, A2A and A2B receptors respectively). Causes a sustained fall in blood pressure and heart rate in spontaneous hypertensive rats and inhibits adenosine deaminase-stimulated lipolysis in rat adipocytes (Ki = 8 nM).

Technical Data

M.Wt:
363.41
Formula:
C17H25N5O4
Solubility:
Soluble to 100 mM in 1.1eq. NaOH and to 100 mM in DMSO
Purity:
>99 %
Storage:
Desiccate at +4°C
CAS No:
130714-47-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

Jacobson and Gao (2006) Adenosine receptors as therapeutic targets. Nat.Rev.Drug Discov. 5 247. PMID: 16518376.

Ishikawa et al (1998) Hypoglycemic and hypotensive effects of 6-cyclohexyl-2'-O-methyl-adenosine, an adenosine A1 receptor agonist, in spontaneous hypertensive rat complicated with hyperglycemia. Diabetes Res.Clin.Pract. 39 3. PMID: 9597368.

Wagner et al (1995) General pharmacology of SDZ WAG 994, a potent selective and orally active adenosine A1 receptor agonist. Drug Dev.Res. 34 276.

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Keywords: SDZ WAG 994, supplier, Potent, selective, A1, agonists, Receptors, adenosines, SDZWAG994, Tocris Bioscience, A1 Receptor Agonist products

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