TNP-ATP triethylammonium salt
Cat. No. 2464
Chemical Name: 2',3'-O-(2,4,6-Trinitrophenyl)adenosi
Biological ActivityHigh affinity, selective P2X receptor antagonist. Inhibits ATP-induced currents in cells expressing P2X1, P2X3 and heteromeric P2X2/3 receptors with IC50 values of 6, 0.9 and 7 nM respectively. Displays 1000-fold selectivity over P2X2, P2X4 and P2X7.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Spelta et al (2002) Kinetics of antagonist actions at rat P2X2/3 heteromeric receptors. Br.J.Pharmacol. 135 1524. PMID: 11906966 .
Burgard et al (2000) Competitive antagonism of recombinant P2X(2/3) receptors by 2', 3'-O-(2,4,6-trinitrophenyl) adenosine 5'-triphosphate (TNP-ATP). Mol.Pharmacol. 58 1502. PMID: 11093790.
Lewis et al (1998) 2',3'-O-(2,4,6-trinitrophenyl) adenosine 5'-triphosphate (TNP-ATP) - a nanomolar affinity antagonist at rat mesenteric artery P2X receptor ion channels. Br.J.Pharmacol. 124 1463. PMID: 9723959.
Thomas et al (1998) The antagonist trinitrophenyl-ATP reveals co-existence of distinct P2X receptor channels in rat nodose channels. J.Physiol. 509.2 411. PMID: 9575290.
Virginio et al (1998) Trinitrophenyl-substituted nucleotides are potent antagonists selective for P2X1, P2X3 and heteromeric P2X2/3 receptors. Mol.Pharmacol. 53 969. PMID: 9614197.
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Citations are publications that use Tocris products. Selected citations for TNP-ATP triethylammonium salt include:
Ghalali et al (2014) Phosphatase and tensin homolog deleted on chromosome 10 (PTEN) and PH domain and leucine-rich repeat phosphatase cross-talk (PHLPP) in cancer cells and in transforming growth factor β-activated stem cells. J Biol Chem 289 11601. PMID: 24599953.
Shabir et al (2013) Functional expression of purinergic P2 receptors and transient receptor potential channels by the human urothelium. Naunyn Schmiedebergs Arch Pharmacol 305 F396. PMID: 23720349.
Manohar et al (2012) ATP release and autocrine signaling through P2X4 receptors regulate γδ T cell activation. J Leukoc Biol 92 787. PMID: 22753954.
Do you know of a great paper that uses TNP-ATP triethylammonium salt from Tocris? If so please let us know.
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Keywords: TNP-ATP triethylammonium salt, supplier, Potent, selective, P2X, antagonists, Receptors, Purinergic, purinoceptors, Tocris Bioscience, Purinergic (P2X) Receptor Antagonist products
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