TNP-ATP triethylammonium salt

Cat. No. 2464

TNP-ATP triethylammonium salt C16H13N8O19P3.C24H64N4 [61368-63-6]

Price and Availability

For TNP-ATP triethylammonium salt pricing & availability please select your country from the drop down menu:
Submit
By clicking submit you agree to accept a cookie from Tocris Bioscience. For details, please read our privacy and cookie policy.

Chemical Name: 2',3'-O-(2,4,6-Trinitrophenyl)adenosine-5'-triphosphate tetra(triethylammonium) salt

Biological Activity

High affinity, selective P2X receptor antagonist. Inhibits ATP-induced currents in cells expressing P2X1, P2X3 and heteromeric P2X2/3 receptors with IC50 values of 6, 0.9 and 7 nM respectively. Displays 1000-fold selectivity over P2X2, P2X4 and P2X7.

Technical Data

M.Wt:
1123.04
Formula:
C16H13N8O19P3.C24H64N4
Solubility:
Soluble in water (supplied pre-dissolved at a concentration of 10mM)
Purity:
>95 %
Storage:
Desiccate at -20°C
CAS No:
61368-63-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Certificate of Analysis / Product Datasheet
Select another batch:

Lewis et al (1998) 2',3'-O-(2,4,6-trinitrophenyl) adenosine 5'-triphosphate (TNP-ATP) - a nanomolar affinity antagonist at rat mesenteric artery P2X receptor ion channels. Br.J.Pharmacol. 124 1463. PMID: 9723959.

Thomas et al (1998) The antagonist trinitrophenyl-ATP reveals co-existence of distinct P2X receptor channels in rat nodose channels. J.Physiol. 509.2 411.

Virginio et al (1998) Trinitrophenyl-substituted nucleotides are potent antagonists selective for P2X1, P2X3 and heteromeric P2X2/3 receptors. Mol.Pharmacol. 53 969. PMID: 9614197.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for TNP-ATP triethylammonium salt include:

Ghalali et al (2014) Phosphatase and tensin homolog deleted on chromosome 10 (PTEN) and PH domain and leucine-rich repeat phosphatase cross-talk (PHLPP) in cancer cells and in transforming growth factor β-activated stem cells. J Biol Chem 289 11601. PMID: 24599953.

Shabir et al (2013) Functional expression of purinergic P2 receptors and transient receptor potential channels by the human urothelium. Naunyn Schmiedebergs Arch Pharmacol 305 F396. PMID: 23720349.

Manohar et al (2012) ATP release and autocrine signaling through P2X4 receptors regulate γδ T cell activation. J Leukoc Biol 92 787. PMID: 22753954.

Do you know of a great paper that uses TNP-ATP triethylammonium salt from Tocris? If so please let us know.

View Related Products by Product Action

Keywords: TNP-ATP triethylammonium salt, supplier, Potent, selective, P2X, antagonists, Receptors, Purinergic, purinoceptors, Tocris Bioscience, Purinergic (P2X) Receptor Antagonist products

Quick Order

Find multiple products by catalog number

divider line

Pain Research Product Guide

Pain Research Product Guide

Our Pain guide highlights over 280 products for Pain research. Request copy or view PDF today.

divider line

Cardiovascular Research Product Guide

Cardiovascular Research Product Guide

Our Cardiovascular Guide highlights over 250 products for cardiovascular research. Request copy or view PDF today.

divider line

P2 Receptors Review

Written by Kenneth Jacobson

P2X and P2Y Receptors Scientific Review

Our Purine Receptor review gives an overview of the subtypes and structures of the P2 receptor family, and the pharmacological ligands used to study them. Request copy or view PDF today.

divider line

Peripheral Sensitization

Written by Grant D. Nicol and Michael R. Vasko

Pain Life Science Poster

Our Peripheral Sensitization poster gives a summary of the excitatory and inhibitory signaling pathways involved in modulation of peripheral sensitization. Request copy or view PDF today.

divider line

LinkedIn Updates

Follow Tocris on LinkedIn

Follow us on LinkedIn!

Visit our LinkedIn page for the latest Tocris news, events and updates.