Cat. No. 0781

L-694,247 C20H21N5O3S [137403-12-4]

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Chemical Name: 2-[5-[3-(4-Methylsulfonylamino)benzyl-1,2,4-oxadiazol-5-yl]-1H-indol-3-yl]ethanamine

Biological Activity

Selective and extremely potent 5-HT1D receptor agonist.

Licensing Information

Sold with the permission of Merck Sharp and Dohme Ltd.

Technical Data

Soluble to 100 mM in DMSO
>98 %
Desiccate at +4°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Buhlen et al (1996) Evidence for presynaptic location of inhibitory 5-HT1Dβ -like autoreceptors in the guinea-pig brain cortex. Naunyn Schmiedebergs Arch.Pharmacol. 353 281. PMID: 8692282.

Heald et al (1994) [3H]L-694,247 labels the 5-HT1Dβ receptor in pig caudate membranes. Eur.J.Pharmacol. 264 213. PMID: 7851485.

Beer et al (1993) L-694,247: a potent 5-HT1D receptor agonist. Br.J.Pharmacol. 110 1196. PMID: 8298808.

Street et al (1993) Synthesis and serotonergic activity of 5-(oxadiazoyl)tryptamines: potent agonists of 5-HT1D receptors. J.Med.Chem. 36 1529. PMID: 8496922.

If you know of a relevant reference for L-694,247 please let us know.

Citations are publications that use Tocris products. Selected citations for L-694,247 include:

Bhalla et al (2001) Molecular cloning, pharmacological properties and tissue distribution of the porcine 5-HT(1B) receptor. Br J Pharmacol 133 891. PMID: 11454663.

Do you know of a great paper that uses L-694,247 from Tocris? If so please let us know.

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Keywords: L-694,247, supplier, 5-HT1D, agonists, Serotonin, Receptors, L694247, merck, Tocris Bioscience, 5-HT1D Receptor Agonist products

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5-HT Scientific Review

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5-HT Receptors Scientific Review

Our 5-HT review summarizes the serotonin receptor subtypes and highlights their importance in mediating various physiological & pharmacological processes. Request copy or view PDF today.

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