Cat. No. 0681

L-690,330 C8H12O8P2 [142523-38-4]

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Chemical Name: [1-(4-Hydroxyphenoxy)ethylidene]bisphosphonic acid

Biological Activity

A potent inhibitor of inositol monophophatase; stable to hydrolysis. Induces autophagy in COS-7 cells independently of mTOR inhibition.

Licensing Information

Sold with the permission of Merck Sharp and Dohme Ltd.

Technical Data

Soluble to 100 mM in water with gentle warming
Store at RT

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Fleming et al (2011) Chemical modulators of autophagy as biological probes and potential therapeutics. Nat.Chem.Biol. 7 9. PMID: 21164513.

Sarkar et al (2005) Lithium induces autophagy by inhibiting inositol monophosphatase. J.Cell.Biol. 170 1101. PMID: 16186256.

Atack et al (1994) Effects of L-690,488, a pro-drug of the bisphosphonate inisotol monophosphatase inhibitor L-690,330, on phosphatidylinisotol cycle markers. J.Pharmacol.Exp.Ther. 270 70. PMID: 8035344.

Atack et al (1993) In vitro and in vivo inhibition of inositol monophosphatase by the bisphosphonate L-690,330. J.Neurochem. 60 652. PMID: 8380439.

If you know of a relevant reference for L-690,330 please let us know.

Citations are publications that use Tocris products. Selected citations for L-690,330 include:

Harding et al (2013) LtpD is a novel Legionella pneumophila effector that binds phosphatidylinositol 3-phosphate and inositol monophosphatase IMPA1. Infect Immun 81 4261. PMID: 24002062.

Meyer et al (2011) Inhibition of inositol monophosphatase by lithium chloride induces selective macrophage apoptosis in atherosclerotic plaques. Br J Pharmacol 162 1410. PMID: 21138421.

Sarkar et al (2008) A rational mechanism for combination treatment of Huntington's disease using lithium and rapamycin. J Cell Biol 17 170. PMID: 17921520.

Criollo et al (2007) Regulation of autophagy by the inositol trisphosphate receptor. Cell Death Differ 14 1029. PMID: 17256008.

Sarkar et al (2005) Lithium induces autophagy by inhibiting inositol monophosphatase. Infect Immun 170 1101. PMID: 16186256.

Westfall et al (2003) Wnt-5/pipetail functions in vertebrate axis formation as a negative regulator of Wnt/beta-catenin activity. J Cell Biol 162 889. PMID: 12952939.

Do you know of a great paper that uses L-690,330 from Tocris? If so please let us know.show all ▼show less ▲

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Keywords: L-690,330, supplier, Inositol, monophosphatase, inhibitors, inhibits, PIP2, Lipids, Ins145P3, 5-Phosphatase, IMPase, Phosphatases, L690330, Tocris Bioscience, Inositol Phosphatase Inhibitor products

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