Arcyriaflavin A

Cat. No. 2457

Arcyriaflavin A C20H11N3O2 [118458-54-1]

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Chemical Name: 12,13-Dihydro-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazole-5,7(6H)-dione

Biological Activity

Potent inhibitor of cdk4/cyclin D1 (IC50 = 59 nM). Also active against CaM kinase II (IC50 = 25 nM) but displays selectivity over several other kinases in vitro (IC50 values for inhibition of PKA and PKC are > 2 and > 100 μM respectively). Inhibits human cytomegalovirus (HCMV) replication in vitro (IC50 = 200 nM).

Technical Data

M.Wt:
325.32
Formula:
C20H11N3O2
Solubility:
Soluble to 100 mM in DMSO
Purity:
>98 %
Storage:
Store at -20°C
CAS No:
118458-54-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Sanchez-Martinez et al (2003) Aryl[a]pyrrolo[3,4-c]carbazoles as selective cyclin D1-CDK4 inhibitors. Bioorg.Med.Chem.Lett. 13 3835. PMID: 14552791.

Zhu et al (2003) Synthesis of quinolinyl/isoquinolinyl[a]pyrrolo [3,4-c] carbazoles as cyclin D1/CDK4 inhibitors. Bioorg.Med.Chem.Lett. 13 1231. PMID: 12657252.

Slater et al (1999) Indolocarbazoles: potent, selective inhibitors of human cytomegalovirus replication. Bioorg.Med.Chem. 7 1067. PMID: 10428375.

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Keywords: Arcyriaflavin A, supplier, Potent, CaM, Kinase, II, cdk4, cyclin, D1, inhibitors, inhibits, Antiviral, agent, anti-HCMV, Calmodulin-Activated, calmodulin-dependent, Protein, Kinases, Cdk, Cyclin-Dependent, Ca2+, Binding, modulators, Calmodulin, Calcium, Signaling, Signalling, ArcyriaflavinA, Tocris Bioscience, Cyclin-Dependent Protein Kinase Inhibitor products

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