Ketanserin tartrate

Cat. No. 0908

Ketanserin tartrate C22H22FN3O3.C4H6O6 [83846-83-7]

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Alternative Name: R 41 468

Chemical Name: 3-[2-[4-(4-Fluorobenzoyl)-1-piperidinyl]ethyl]-2,4[1H,3H]-quinazolinedione tartrate

Biological Activity

Selective 5-HT2A serotonin receptor antagonist; can also be used to discriminate between 5-HT1D and 5-HT1B receptor subtypes.

Technical Data

M.Wt:
545.52
Formula:
C22H22FN3O3.C4H6O6
Solubility:
Soluble to 10 mM in water
Purity:
>97 %
Storage:
Store at RT
CAS No:
83846-83-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
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Safety Data Sheet: View Safety Data Sheet

Razzaque et al (1995) Differences in the effects of ketanserin and GR 127935 on 5-HT-receptor mediated responses in rabbit saphenous vein and guinea-pig jugular vein. Eur.J.Pharmacol. 283 199. PMID: 7498311.

Zgombick et al (1995) Ketanserin and ritanserin discriminate between recombinant human 5-HT1Dα and 5-HT1Dβ receptor subtypes. Eur.J.Pharmacol. 291 9. PMID: 8549648.

Leyson et al (1981) Receptor binding profile of R41 468, a novel antagonist at 5-HT2 receptors. Life Sci. 28 1015. PMID: 6261070.

Van Nueten et al (1981) Vascular effects of ketanserin (R41 468), a novel antagonist of 5-HT2 serotonergic receptors. J.Pharmacol.Exp.Ther. 218 217. PMID: 6113280.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for Ketanserin tartrate include:

Johnson et al (2011) Serotonin receptor activity is necessary for olfactory learning and memory in Drosophila melanogaster. Neuroscience 192 372. PMID: 21749913.

Kleinbongard et al (2011) Vasoconstrictor potential of coronary aspirate from patients undergoing stenting of saphenous vein aortocoronary bypass grafts and its pharmacological attenuation. Circ Res 108 344. PMID: 21183739.

Wood et al (2011) Serotonin, via HTR2 receptors, excites neurons in a cortical-like premotor nucleus necessary for song learning and production. J Neurosci 31 13808. PMID: 21957243.

Do you know of a great paper that uses Ketanserin tartrate from Tocris? If so please let us know.

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Keywords: Ketanserin tartrate, supplier, Selective, 5-HT2A, antagonist, 5-HT1D, Serotonin, Receptors, R41468, Tocris Bioscience, 5-HT2A Receptor Antagonist products

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