Ketanserin tartrate

Cat. No. 0908

Ketanserin tartrate C22H22FN3O3.C4H6O6 [83846-83-7]

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Alternative Name: R 41 468

Chemical Name: 3-[2-[4-(4-Fluorobenzoyl)-1-piperidinyl]ethyl]-2,4[1H,3H]-quinazolinedione tartrate

Biological Activity

Selective 5-HT2A serotonin receptor antagonist; can also be used to discriminate between 5-HT1D and 5-HT1B receptor subtypes.

Technical Data

Soluble to 10 mM in water
>97 %
Store at RT

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

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Safety Data Sheet: View Safety Data Sheet

Razzaque et al (1995) Differences in the effects of ketanserin and GR 127935 on 5-HT-receptor mediated responses in rabbit saphenous vein and guinea-pig jugular vein. Eur.J.Pharmacol. 283 199. PMID: 7498311.

Zgombick et al (1995) Ketanserin and ritanserin discriminate between recombinant human 5-HT1Dα and 5-HT1Dβ receptor subtypes. Eur.J.Pharmacol. 291 9. PMID: 8549648.

Leyson et al (1981) Receptor binding profile of R41 468, a novel antagonist at 5-HT2 receptors. Life Sci. 28 1015. PMID: 6261070.

Van Nueten et al (1981) Vascular effects of ketanserin (R41 468), a novel antagonist of 5-HT2 serotonergic receptors. J.Pharmacol.Exp.Ther. 218 217. PMID: 6113280.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for Ketanserin tartrate include:

Fanarioti et al (2015) Behavioral and neurochemical changes in mesostriatal dopaminergic regions of the rat after chronic administration of the cannabinoid receptor agonist WIN55,212-2. Synapse 18. PMID: 25522428.

Jiang et al (2015) Potentiation of 5-methoxy-N,N-dimethyltryptamine-induced hyperthermia by harmaline and the involvement of activation of 5-HT1A and 5-HT2A receptors. Br J Pharmacol 89 342. PMID: 25446678.

Kasper et al (2015) Serotonin-2C receptor agonists decrease potassium-stimulated GABA release in the nucleus accumbens. Neuropharmacology 69 78. PMID: 25382408.

Morecroft et al (2012) Gene therapy by targeted adenovirus-mediated knockdown of pulmonary endothelial Tph1 attenuates hypoxia-induced pulmonary hypertension. Cereb Cortex 20 1516. PMID: 22525513.

Ratner et al (2012) Cerebral markers of the serotonergic system in rat models of obesity and after Roux-en-Y gastric bypass. Neuron 20 2133. PMID: 22450706.

Johnson et al (2011) Serotonin receptor activity is necessary for olfactory learning and memory in Drosophila melanogaster. Neuroscience 192 372. PMID: 21749913.

Kleinbongard et al (2011) Vasoconstrictor potential of coronary aspirate from patients undergoing stenting of saphenous vein aortocoronary bypass grafts and its pharmacological attenuation. Circ Res 108 344. PMID: 21183739.

Wood et al (2011) Serotonin, via HTR2 receptors, excites neurons in a cortical-like premotor nucleus necessary for song learning and production. J Neurosci 31 13808. PMID: 21957243.

Morecroft et al (2010) In vivo effects of a combined 5-HT1B receptor/SERT antagonist in experimental pulmonary hypertension. Int J Neuropsychopharmacol 85 593. PMID: 19736308.

Watakabe et al (2009) Enriched expression of serotonin 1B and 2A receptor genes in macaque visual cortex and their bidirectional modulatory effects on neuronal responses. Br J Pharmacol 19 1915. PMID: 19056862.

González-Maeso et al (2007) Hallucinogens recruit specific cortical 5-HT(2A) receptor-mediated signaling pathways to affect behavior. Mol Ther 53 439. PMID: 17270739.

Morecroft et al (1999) 5-hydroxytryptamine receptors mediating contraction in human small muscular pulmonary arteries: importance of the 5-HT1B receptor. Obesity (Silver Spring) 128 730. PMID: 10516655.

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Keywords: Ketanserin tartrate, supplier, Selective, 5-HT2A, antagonist, 5-HT1D, Serotonin, Receptors, R41468, Tocris Bioscience, 5-HT2A Receptor Antagonist products

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