Leupeptin hemisulfate

Cat. No. 1167

Leupeptin hemisulfate Ac-Leu-Leu-Arginal

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Biological Activity

Reversible inhibitor of trypsin-like and cysteine proteases such as calpain. Shown to inhibit activation-induced programmed cell death.

Technical Data


(Modifications: Leu-1 = N-terminal Ac, Arg-3 = Arginal)

Soluble to 10 mg/ml in water
Desiccate at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

Certificate of Analysis / Product Datasheet
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References are publications that support the products' biological activity.

Sarin et al (1994) Inhibition of activation-induced programmed cell death and restoration of defective immune responses of HIV+ donors by cysteine protease inhibitors. J.Immunol. 153 862. PMID: 8021517.

Mehdi (1991) Cell-penetrating inhibitors of calpain. TiBS 16 150. PMID: 1877091.

Wang (1990) Developing selective inhibitors of calpain. TiPS 11 139. PMID: 2185586.

If you know of a relevant reference for Leupeptin hemisulfate please let us know.

Citations are publications that use Tocris products. Selected citations for Leupeptin hemisulfate include:

Haller et al (2015) Ubiquitination and proteasomal degradation of ATG12 regulates its proapoptotic activity. J Pharmacol Exp Ther 10 2269. PMID: 25629932.

Do you know of a great paper that uses Leupeptin hemisulfate from Tocris? If so please let us know.

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Keywords: Leupeptin hemisulfate, supplier, inhibitors, inhibits, trypsin-like, cysteine, proteases, Proteases, Proteinases, Tocris Bioscience, Other Protease Inhibitor products

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