Cat. No. 0307
Biological ActivityDemonstrates high affinity for the kainate receptor subtype hGluR5 (Ki = 0.24 nM) and 600-4000-fold selectivity over both the AMPA receptor subtypes and the homomeric kainate receptor hGluR6.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Swanson et al (1998) Kainate receptors exhibit differential sensitivities to (S)-5-iodowillardiine. Mol.Pharmacol. 53 942. PMID: 9584222.
Jane et al (1997) Synthesis of willardiine and 6-azawillardiine analogs: pharmacological characterization on cloned homomeric human AMPA and kainate receptor subtypes. J.Med.Chem. 40 3645. PMID: 9357531.
Thompson et al (1996) Depolarising effects of certain derivatives of (S) willardiine upon in vitro neonatal rat dorsal roots. Br.J.Pharmacol. 117 331P.
Wong et al (1994) Willardiines differentiate agonist binding sites for kainate-versus AMPA-preferring glutamate receptors in DRG and hippocampal neurones. J.Neurosci. 14 3881. PMID: 7515954.
Patneau et al (1992) Activation and desensitization of AMPA/kainate receptors by novel derivatives of willardiine. J.Neurosci. 12 595. PMID: 1371315.
If you know of a relevant reference for (S)-(-)-5-Iodowillardiine please let us know.
Citations are publications that use Tocris products. Selected citations for (S)-(-)-5-Iodowillardiine include:
Pansiot et al (2010) Neuroprotective effect of inhaled nitric oxide on excitotoxic-induced brain damage in neonatal rat. Proc Natl Acad Sci U S A 5 e10916. PMID: 20532231.
Do you know of a great paper that uses (S)-(-)-5-Iodowillardiine from Tocris? If so please let us know.
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Keywords: (S)-(-)-5-Iodowillardiine, supplier, potent, subtype, selective, kainate, agonists, Glutamate, Kainate, Receptors, iGluR, Ionotropic, Tocris Bioscience, Kainate Receptor Agonist products