Cat. No. 0307
Biological ActivityDemonstrates high affinity for the kainate receptor subtype hGluR5 (Ki = 0.24 nM) and 600-4000-fold selectivity over both the AMPA receptor subtypes and the homomeric kainate receptor hGluR6.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Swanson et al (1998) Kainate receptors exhibit differential sensitivities to (S)-5-iodowillardiine. Mol.Pharmacol. 53 942. PMID: 9584222.
Jane et al (1997) Synthesis of willardiine and 6-azawillardiine analogs: pharmacological characterization on cloned homomeric human AMPA and kainate receptor subtypes. J.Med.Chem. 40 3645. PMID: 9357531.
Thompson et al (1996) Depolarising effects of certain derivatives of (S) willardiine upon in vitro neonatal rat dorsal roots. Br.J.Pharmacol. 117 331P.
Wong et al (1994) Willardiines differentiate agonist binding sites for kainate-versus AMPA-preferring glutamate receptors in DRG and hippocampal neurones. J.Neurosci. 14 3881. PMID: 7515954.
Patneau et al (1992) Activation and desensitization of AMPA/kainate receptors by novel derivatives of willardiine. J.Neurosci. 12 595. PMID: 1371315.
If you know of a relevant reference for this product please let us know.
Citations are publications that use Tocris products.
Do you know of a great paper that uses (S)-(-)-5-Iodowillardiine from Tocris? If so please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: (S)-(-)-5-Iodowillardiine, supplier, potent, subtype, selective, kainate, agonists, Glutamate, Kainate, Receptors, iGluR, Ionotropic, Tocris Bioscience, Kainate Receptor Agonist products
Find multiple products by catalog number
New Products in this Area
Potent NMDA receptor antagonist; NR2A selectivecis-6-Hydroxynorketamine hydrochloride
Metabolite of ketamine (Cat.No. 3131); antidepressive
Follow Tocris on LinkedIn
Visit our LinkedIn page for the latest Tocris news, events and updates.