Kynurenic acid

Cat. No. 0223

Kynurenic acid C10H7NO3 [492-27-3]

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Chemical Name: 4-Hydroxyquinoline-2-carboxylic acid

Biological Activity

Broad spectrum EAA antagonist. Putative GPR35 ligand. Kynurenic acid sodium salt also available (Cat. No. 3694).

Technical Data

M.Wt:
189.17
Formula:
C10H7NO3
Solubility:
Soluble to 50 mM in DMSO and to 100 mM in 1eq. NaOH
Purity:
>98 %
Storage:
Store at RT
CAS No:
492-27-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
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Safety Data Sheet: View Safety Data Sheet

Wang et al (2006) Kynurenic acid as a ligand for orphan G protein-coupled receptor GPR35. J.Biol.Chem. 281 22021. PMID: 16754668.

Pittaluga et al (1997) The 'kynurenate test,' a biochemical assay for putative cognition enhancers. J.Pharmacol.Exp.Ther. 283 82. PMID: 9336311.

Stone and Burton (1988) NMDA receptors and ligands in the vertebrate CNS. Prog.Neurobiol. 30 333. PMID: 2830636.

Perkins and Stone (1982) An iontophoretic investigation of the actions of convulsant kynurenines and their interaction with the endogenous excitant quinolinic acid. Brain Res. 247 184. PMID: 6215086.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for Kynurenic acid include:

Carver et al (2014) Perimenstrual-like hormonal regulation of extrasynaptic δ-containing GABAA receptors mediating tonic inhibition and neurosteroid sensitivity. J Neurosci 34 14181. PMID: 25339733.

Weston et al (2014) Loss of mTOR repressors Tsc1 or Pten has divergent effects on excitatory and inhibitory synaptic transmission in single hippocampal neuron cultures. Front Mol Neurosci 7 1. PMID: 24574959.

Wu et al (2013) Estrous cycle regulation of extrasynaptic δ-containing GABA(A) receptor-mediated tonic inhibition and limbic epileptogenesis. J Pharmacol Exp Ther 346 146. PMID: 23667248.

Zhu et al (2011) Suppression of PKR promotes network excitability and enhanced cognition by interferon-γ-mediated disinhibition. Cell 147 1384. PMID: 22153080.

Do you know of a great paper that uses Kynurenic acid from Tocris? If so please let us know.show all ▼show less ▲

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Keywords: Kynurenic acid, supplier, Broad, spectrum, EAA, antagonists, Glutamate, Ionotropic, Non-Selective, iGluR, Receptors, mGlur, Metabotropic, Tocris Bioscience, Non-selective Ionotropic Glutamate Antagonist products

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