CGRP (rat)

Cat. No. 1161

CGRP (rat) Ser-Cys-Asn-Thr-Ala-Thr-Cys-Val-Thr-His-Arg-Leu-Ala-Gly-Leu-Leu-Ser-Arg-Ser-Gly-Gly-Val-Val-Lys-Asp-Asn-Phe-Val-Pro-Thr-Asn-Val-Gly-Ser-Glu-Ala-Phe-NH2 (Disulfide bridge: 2-7)

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Alternative Name: Calcitonin Gene-Related Peptide (rat)

Biological Activity

Endogenous neuropeptide; potent vasodilator which also exerts cardiovascular, pro-inflammatory and metabolic effects.

Technical Data

M.Wt:
3807
Formula:
C162H262N50O52S2
Sequence:
SCNTATCVTHRLAGLLSRSGGVVKDNFVPTNVGSEAF

(Modifications: Disulfide bridge between 2 - 7, Phe-37 = C-terminal amide)

Solubility:
Soluble to 0.80 mg/ml in water
Storage:
Desiccate at -20°C
CAS No:
83651-90-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Certificate of Analysis / Product Datasheet
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Nakamura et al (1998) Calcitonin gene-related peptide as a GH secretagogue in human and rat pituitary somatotrophs. Brain Res. 807 203. PMID: 9757038.

Salim et al (1998) Calcitonin gene-related peptide potentiates nicotinic acetylcholine receptor-operated slow Ca2+ mobilization at mouse muscle endplates. Br.J.Pharmacol. 125 277. PMID: 9786499.

Poyner (1995) Pharmacology of receptors for calcitonin gene-related peptide and amylin. TiPS 16 424. PMID: 8578616.

Brain et al (1985) Calcitonin gene-related peptide is a potent vasodilator. Nature 313 54. PMID: 3917554.

Morris et al (1984) Isolation and characterization of human calcitonin gene-related peptide. Nature 308 746. PMID: 6609312.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for CGRP (rat) include:

Xiao et al (2008) Release of glutamate and CGRP from trigeminal ganglion neurons: Role of calcium channels and 5-HT1 receptor signaling. Elife 4 12. PMID: 18416824.

Holland et al (2005) Orexin 1 receptor activation attenuates neurogenic dural vasodilation in an animal model of trigeminovascular nociception. Mol Pain 315 1380. PMID: 16160082.

Do you know of a great paper that uses CGRP (rat) from Tocris? If so please let us know.

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Keywords: CGRP (rat), supplier, Potent, vasodilator, CGRP, Receptors, calcitonin-gene, related, peptide, AMY1, AMY2, AMY3, agonists, Tocris Bioscience

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