Cat. No. 0544

IPAG C17H22IN3 [193527-91-2]

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Chemical Name: 1-(4-Iodophenyl)-3-(2-adamantyl)guanidine

Biological Activity

Potent σ-receptor antagonist.

Technical Data

Soluble to 50 mM in ethanol and to 100 mM in DMSO
>98 %
Store at RT

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Whittemore et al (1997) Antagonism of N-methyl-D-aspartate receptors by σ site ligands: potency, subtype-selectivity and mechanisms of inhibition. J.Pharmacol.Exp.Ther. 282 326. PMID: 9223571.

Wilson et al (1991) Radiosynthesis of σ receptor ligands for positron emission tomography: 11C- and 18F-labelled guanidines. J.Med.Chem. 34 1867. PMID: 1648140.

If you know of a relevant reference for IPAG please let us know.

Citations are publications that use Tocris products. Selected citations for IPAG include:

Kim et al (2012) Inhibition of tumor cell growth by Sigma1 ligand mediated translational repression. Biochem Biophys Res Commun 426 177. PMID: 22925888.

Do you know of a great paper that uses IPAG from Tocris? If so please let us know.

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Keywords: IPAG, supplier, Potent, σ, sigma, antagonists, General, Receptors, Tocris Bioscience, Sigma-Related Antagonist products

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