Iodophenpropit dihydrobromide

Cat. No. 0779

Iodophenpropit dihydrobromide C15H19IN4S.2HBr [145196-87-8]

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Chemical Name: N-[2-(4-Iodophenyl)ethyl]-S-[3-(4(5)-imidazolyl)propyl]isothiourea dihydrobromide

Biological Activity

Selective H3 antagonist with high affinity (KD = 0.3 nM). Also available as part of the Histamine H3 Receptor Tocriset™.

Licensing Information

Sold with the permission of SCI, Amsterdam

Technical Data

Soluble to 25 mM in water
>98 %
Desiccate at +4°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Shahid et al (2009) Histamine, histamine receptors, and their role in immunomodulation: An updated systematic review. Open Immunol.J. 2 9.

Jansen et al (1994) Characterisation of the binding of the first selective radiolabelled histamine H3 receptor antagonist, [125I]-iodophenpropit, to rat brain. Br.J.Pharmacol. 113 355. PMID: 7834183.

Jansen et al (1992) The first radiolabelled histamine H3 receptor antagonist, [125I]iodophenpropit: saturable and reversible binding to rat cortex membranes. Eur.J.Pharmacol. 217 203. PMID: 1330590.

Menge et al (1992) Synthesis of S-[3-(4(5)-imidazolyl)propyl]-N-[2-(4-[125I]-iodophenylethyl]isothiourea sulfate [125I]-iodophenpropit), a new probe for histamine H3 receptor binding sites. J.Labelled Comp.Radiopharm. XXXI 10 781.

If you know of a relevant reference for Iodophenpropit dihydrobromide please let us know.

Citations are publications that use Tocris products. Selected citations for Iodophenpropit dihydrobromide include:

Otvos et al (2015) Development of Plate Reader and On-Line Microfluidic Screening to Identify Ligands of the 5-Hydroxytryptamine Binding Protein in Venoms. BMC Neurosci 7 2336. PMID: 26114334.

Spaethling et al (2014) Serotonergic neuron regulation informed by in vivo single-cell transcriptomics. Toxins (Basel) 28 771. PMID: 24192459.

Do you know of a great paper that uses Iodophenpropit dihydrobromide from Tocris? If so please let us know.

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Keywords: Iodophenpropit dihydrobromide, supplier, Potent, selective, H3, antagonists, Receptors, Histamine, histaminergic, Tocris Bioscience, Histamine H3 Receptor Antagonist products

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