CGP 53353

Cat. No. 2442

CGP 53353 C20H13F2N3O2 [145915-60-2]

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Chemical Name: 5,6-bis[(4-Fluorophenyl)amino]-1H-isoindole-1,3(2H)-dione

Biological Activity

Selective inhibitor of PKCβII (IC50 values are 0.41 and 3.8 μM for PKCβII and PKCβI respectively). Also inhibits prionogenic Sup35 fibrillization (IC50 ~ 3.4 μM) and inhibits de novo Aβ42 assembly in vitro.

Technical Data

M.Wt:
365.34
Formula:
C20H13F2N3O2
Solubility:
Soluble to 100 mM in DMSO and to 20 mM in ethanol
Purity:
>99 %
Storage:
Store at RT
CAS No:
145915-60-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Wang et al (2008) Direct and selective elimination of specific prions and amyloids by 4,5-dianilinophthalimide and analogs. Proc.Natl.Acad.Sci.USA 105 7159.

Kouroedov et al (2004) Selective inhibition of protein kinase Cβ2 prevents acute effects of high glucose on vascular cell adhesion molecule-1 expression in human endothelial cells. Circulation 110 91. PMID: 15210597.

If you know of a relevant reference for CGP 53353 please let us know.

Citations are publications that use Tocris products. Selected citations for CGP 53353 include:

Liu et al (2014) PKCβII acts downstream of chemoattractant receptors and mTORC2 to regulate cAMP production and myosin II activity in neutrophils. Mol Biol Cell 25 1446. PMID: 24600048.

He et al (2011) Stanniocalcin-1 promotes tumor angiogenesis through up-regulation of VEGF in gastric cancer cells. J Neurosci 18 39. PMID: 21672207.

Do you know of a great paper that uses CGP 53353 from Tocris? If so please let us know.

View Related Products by Product Action

Keywords: CGP 53353, supplier, Selective, inhibitors, inhibits, PKCbetaII, de, novo, Aβ4, β42, beta42, assesmbly, PKC, PKM, Protein, Kinase, C, Kinases, b-amyloid, β-Amyloid, beta-Amyloid, Precursor, APP, Secretase, beta, Peptides, prionogenic, Sup35, fibrillization, CGP53353, amyloidbeta, amyloidb, amyloidβ, Tocris Bioscience, Protein Kinase C Inhibitor products

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